Tissue reaction and anti-biofilm action of new biomaterial composed of latex from Hancornia speciosa Gomes and silver nanoparticles

Autor(es)

JÉSSICA M. BONETE ^[1] ; GUILHERME D. SILVA ^[2] ; ÉDER J. GUIDELLI ^[3] ; PABLO J. GONÇALVES ^[4] ; LUCIANE M. ALMEIDA ^[5] ; OSWALDO BAFFA ^[6] ; ANGELA KINOSHITA

Afiliação do(s) autor(es)

^[1] Universidade do Sagrado Coração/USC - Brasil

^[2] Universidade do Sagrado Coração/USC - Brasil

^[3] Universidade de São Paulo/FFCLRP. Departamento de Física - Brasil

^[4] Universidade Federal de Goiás/UFG. Instituto Física - Brasil

^[5] Universidade Estadual de Goiás/UEG - Brasil

^[6] Universidade de São Paulo/FFCLRP. Departamento de Física - Brasil

• Tipo de documento: Artigo Científico
• Fonte: Anais da Academia Brasileira de Ciências; v. 92, n. 4 2020-11-16.

Resumo

Abstract In this work, the natural latex extracted from Harconia speciosa was incorporated with silver nanoparticles (AgNP) to compose a functional biomaterial associating the intrinsic angiogenic activity of the latex and the antimicrobial activity of AgNP. Tissue reaction after subcutaneous implantation in dorsum of rats of membranes without AgNP and with 0.05%, 0.4% AgNP was compared at 3, 7 and 25 days. No statistically significant difference in the tissue response of the different biomaterials was observed, indicating that AgNP did not interfere with the inflammatory reaction (p > 0.05) or with the angiogenic activity of latex. Biomembranes were also tested against bacterial biofilm formation by Staphylococcus aureus and the antimicrobial activity of the new biomaterial can be found with bacteria crenation (0.05% AgNP) and no biofilm deposition (0.4% AgNP). Therefore, this biomaterial has interesting properties for the tissue repair process and may be feasible for future applications as dressing. (AU)

• Processo FAPESP: 13/07699-0 - Centro de Pesquisa, Inovação e Difusão em Neuromatemática - NeuroMat
• Beneficiário: Oswaldo Baffa Filho
• Modalidade de apoio: Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs
• Processo FAPESP: 16/06399-0 - Desenvolvimento e estudo da reação tecidual de um novo biomaterial composto de látex Hancornia speciosa Gomes e nanopartículas de prata
• Beneficiário: Jéssica Mariana Bonete
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica