Association between cognitive performance and self-reported glaucoma in middle-aged and older adults: a cross-sectional analysis of ELSA-Brasil

Autor(es):Mostrar menos -

K.S. Vidal ^[1] ; C.K. Suemoto ^[2] ; A.B. Moreno ^[3] ; B. Duncan ^[4] ; M.I. Schmidt ^[5] ; M. Maestri ^[6] ; S.M. Barreto ^[7] ; P.A. Lotufo ; L. Bertola ^[9] ; I.M. Bensenor ; A.R. Brunoni

Afiliação do(s) autor(es):Mostrar menos -

^[1] Instituto de Psicologia, Universidade de São Paulo. Laboratório da Visão - Brasil

^[2] Divisão de Geriatria, Faculdade de Medicina, Universidade de São Paulo - Brasil

^[3] Departamento de Epidemiologia e Métodos Quantitativos na Saúde, Escola Nacional de Saúde Pública, Fundação Oswaldo Cruz - Brasil

^[4] Departamento de Epidemiologia, Universidade Federal do Rio Grande do Sul - Brasil

^[5] Departamento de Epidemiologia, Universidade Federal do Rio Grande do Sul - Brasil

^[6] Departamento de Oftalmologia e Otorrinolaringologia, Faculdade de Medicina, Universidade do Rio Grande do Sul - Brasil

^[7] Faculdade de Medicina e Hospital das Clínicas, Universidade Federal de Minas Gerais - Brasil

^[9] Departamento de Medicina Interna, Faculdade de Medicina, Universidade de São Paulo - Brasil

• Tipo de documento: Artigo Científico
• Fonte: Brazilian Journal of Medical and Biological Research; v. 53, n. 12 2020-10-30.

Resumo

Recent evidence suggests that glaucoma and Alzheimer's disease are neurodegenerative diseases sharing common pathophysiological and etiological features, although findings are inconclusive. We sought to investigate whether self-reported glaucoma patients without dementia present poorer cognitive performance, an issue that has been less investigated. We employed cross-sectional data from the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil) and included participants ≥50 years of age without a known diagnosis of dementia and a self-reported glaucoma diagnosis. We excluded those with previous stroke, other eye conditions, and using drugs that could impair cognition. We evaluated cognition using delayed word recall, phonemic verbal fluency, and trail making (version B) tests. We used multinomial linear regression models to investigate associations between self-reported glaucoma with cognition, adjusted by several sociodemographic and clinical variables. Out of 4,331 participants, 139 reported glaucoma. Fully-adjusted models showed that self-reported glaucoma patients presented poorer performance in the verbal fluency test (β=-0.39, 95%CI=-0.64 to -0.14, P=0.002), but not in the other cognitive assessments. Thus, our results support the hypothesis that self-reported glaucoma is associated with poor cognitive performance; however, longitudinal data are necessary to corroborate our findings. (AU)

• Processo FAPESP: 15/22227-2 - Avaliação eletrofisiológica e psicofísica das funções visuais: estudo comparativo nas doenças de Alzheimer, neuropatia glaucomatosa e degeneração macular relacionada à idade
• Beneficiário: Kallene Summer Moreira Vidal
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado