Application of experimental design to evaluate the incorporation of naproxen into sericin/alginate particles prepared by ionic gelation technique

Autor(es)

Freitas, E. D. ^[1] ; Rosa, P. C. P. ^[2] ; Silva, M. G. C. ^[1] ; Vieira, M. G. A. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Campinas UNICAMP, Sch Chem Engn, Dept Proc & Prod Design, Albert Einstein Ave 500, BR-13083852 Campinas, SP - Brazil

^[2] Univ Campinas UNICAMP, Sch Med Sci, Dept Pharmacol, Tessalia Vieira Camargo St, BR-13083887 Campinas, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Chemical Engineering Science; v. 229, JAN 16 2021.
• Citações Web of Science: 0

Resumo

The polymeric blend of sericin and alginate has already shown good results for the incorporation of naproxen, achieving delayed and prolonged release. Thus, in this paper, it was aimed to optimize formu-lations of naproxen-loaded sericin and alginate blend, using the technique of experimental design. Initial amounts of alginate and drug were evaluated on entrapment efficiency, drug loading and time to release 85% of drug (t(85)). Efficiency was not affected statistically, while drug loading was higher for higher amounts of naproxen. In addition, the longest release times were achieved for greater amounts of drug and/or alginate, and the presence of sericin proved to be essential to extend the release of naproxen. The analytical characterizations of the particles showed the incorporation of the drug mainly in its original crystalline form, with part being physically mixed with the matrix. In addition, both the matrix and the drug loaded matrix demonstrated biocompatibility with HaCaT cell line. (c) 2020 Elsevier Ltd. All rights reserved. (AU)

• Processo FAPESP: 15/13505-9 - Incorporação e liberação de fármacos em micropartículas de sericina e alginato
• Beneficiário: Melissa Gurgel Adeodato Vieira
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 16/05007-1 - Remoção de fármacos residuais em solução aquosa por adsorventes alternativos
• Beneficiário: Meuris Gurgel Carlos da Silva
• Modalidade de apoio: Auxílio à Pesquisa - Regular