Evaluation of different solvents and solubility parameters on the morphology and diameter of electrospun pullulan nanofibers for curcumin entrapment

Autor(es)

Guerrini, Lilia M. ^[1] ; Oliveira, Mauricio P. ^{[1, 2]} ; Stapait, Camila C. ^[3] ; Maric, Milan ^[2] ; Santos, Amilton M. ^[4] ; Demarquette, Nicole R. ^[3]

Afiliação do(s) autor(es)

^[1] Univ Fed Sao Paulo, Dept Sci & Technol, Inst Sci & Technol, Sao Jose Dos Campos - Brazil

^[2] McGill Univ, Dept Chem Engn, Montreal, PQ - Canada

^[3] Ecole Technol Super ETS, Dept Mech Engn, Montreal, PQ - Canada

^[4] Univ Sao Paulo, Dept Chem Engn, Sch Engn Lorena, Lorena - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Carbohydrate Polymers; v. 251, JAN 1 2021.
• Citações Web of Science: 0

Resumo

In this work, the effect of different solvents and solvent binary mixtures on the morphology of electrospun pullulan (Pull) nanofibers was evaluated. The solution viscosities, interactions between solvent and polymer, as well as, solvent vapor pressure, were correlated to the morphology and diameters of the nanofibers. Water, dimethylformamide (DMF) and dimethyl sulfoxide (DMSO) and Teas graphs that rely on the use of Hildebrand solubility parameters were used to identify the most suitable mixtures of solvents. The best binary mixture of solvents to produce Pull nanofibers without defects and with small diameters (203 +/- 32 nm) was DMF/DMSO in the ratio of 70/30 wt.%. Pull nanofibers containing 3 and 5 wt. % of curcumin (Curt) in a mixture of DMF/DMSO (70/30 wt.%) were then obtained, and the entrapment efficiency was evaluated using H-1 NMR and a UV-vis spectrophotometer. The results obtained in this work create a new approach for the production of Pull nanofibers for drug delivery systems. (AU)

• Processo FAPESP: 19/04952-2 - Produção de nanomantas de copolímeros grafitizados de pululana por escalonamento de eletrofiação visando aplicações em liberação de fármacos
• Beneficiário: Lilia Müller Guerrini
• Modalidade de apoio: Bolsas no Exterior - Pesquisa
• Processo FAPESP: 19/05282-0 - Síntese de copolímeros anfifílicos enxertados com polímeros sintético e de fonte renovável visando a produção de nanopartículas e nanomantas para aplicações biomédicas e industriais
• Beneficiário: MAURÍCIO PINHEIRO DE OLIVEIRA
• Modalidade de apoio: Bolsas no Exterior - Pesquisa