Synergistic effect of adding bioglass and carbon nanotubes on poly (lactic acid) porous membranes for guided bone regeneration

Autor(es)

de Moura, Nayara Koba ^[1] ; Martins, Eduardo Ferreira ^[1] ; Moraes Saldanha Oliveira, Rodrigo Luiz ^[1] ; Waltrick de Brito Siqueira, Idalia Aparecida ^[1] ; Barros Machado, Joao Paulo ^[2] ; Esposito, Elisa ^[1] ; Amaral, Suelen Simoes ^[3] ; Reis de Vasconcellos, Luana Marotta ^[3] ; Passador, Fabio Roberto ^[1] ; Triches, Eliandra de Sousa ^[1]

Afiliação do(s) autor(es)

^[1] Fed Univ Sao Paulo UNIFESP, 330 Talim St, BR-12231280 Sao Jose Dos Campos, SP - Brazil

^[2] Natl Inst Space Res INPE, 1758 Astronautas Ave, BR-12227010 Sao Jose Dos Campos, SP - Brazil

^[3] Sao Paulo State Univ UNESP, Inst Sci & Technol, 777 Engn Francisco Jose Longo Ave, BR-12245000 Sao Jose Dos Campos, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Materials Science & Engineering C-Materials for Biological Applications; v. 117, DEC 2020.
• Citações Web of Science: 1

Resumo

Polymer membranes have been widely used in guided bone regeneration (GBR), especially when it comes to their use in dentistry. Poly (lactic acid) (PLA) have good mechanical properties such as flexibility, which allows the material to be moldable and also has biocompatibility and biodegradation. Besides that, bioglass (BG) incorporated into the polymer matrix can promote osteoinduction properties and osteoconduction properties to the polymer-ceramic biocomposite. The membranes are also required to exhibit antimicrobial activity to prevent or control the proliferation of pathogenic microorganisms, and the addition of carbon nanotubes (CNT) can assist in this property. The porous membranes of PLA with the addition of different contents of BG and CNT were obtained by solvent casting in controlled humidity method, and the synergistic effect of the addition of both fillers were investigated. The membranes showed pores (3-11 mu m) on their surface. The addition of 5 wt% BG causes an increase in the surface porosity and bioactivity properties of the PLA. The agar diffusion test showed antimicrobial activity in the membranes with addition of CNT. In vitro results showed that the porous membranes were not cytotoxic and allowed cell activity and differentiation. Thus, BG collaborated to increase biological activity while CNT contributed to microbial activity, creating a synergistic effect on PLA porous membranes, being this effect more evident for PLA/5BG/1.0CNT. These results indicated a promising use of this new biomaterial for the production of porous membranes for GBR. (AU)

• Processo FAPESP: 15/24659-7 - Síntese, caracterização e avaliação de biocompatibilidade de scaffolds bioceramicos preparados pelo método de freeze casting
• Beneficiário: Eliandra de Sousa Trichês
• Linha de fomento: Auxílio à Pesquisa - Regular