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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Thermoprotective molecules to improve oocyte competence under elevated temperature

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Autor(es):
Moura, Marcelo T. [1] ; Paula-Lopes, Fabiola F. [1]
Número total de Autores: 2
Afiliação do(s) autor(es):
[1] Fed Univ Sao Paulo UNIFESP, Dept Biol Sci, Diadema, SP - Brazil
Número total de Afiliações: 1
Tipo de documento: Artigo Científico
Fonte: Theriogenology; v. 156, p. 262-271, OCT 15 2020.
Citações Web of Science: 0
Resumo

Heat stress is an environmental factor that challenges livestock by disturbing animal homeostasis. Despite the broad detrimental effects of heat stress on reproductive function, the germline and the early preimplantation embryo are particularly prone. There is extensive evidence that elevated temperature reduces oocyte developmental competence through a series of cellular and molecular damages. Further research revealed that the oocyte respond to stress by activating cellular mechanisms such as heat shock response, unfolded protein response and autophagy to improve survival under heat shock. Such knowledge paved the way for the identification of thermoprotective molecules that alleviate heat induced oocyte oxidative stress, organelle damage, and apoptosis. Therefore, this review depicts the deleterious effects of heat shock on oocyte developmental competence, heat-induced cellular and molecular changes, outlines pro-survival cellular mechanisms and explores thermoprotective molecules to improve oocyte competence. (c) 2020 Elsevier Inc. All rights reserved. (AU)

Processo FAPESP: 17/20125-3 - Alterações do perfil epigenético imediato e transgeracional causadas pelo estresse térmico no gameta feminino
Beneficiário:Fabíola Freitas de Paula Lopes
Modalidade de apoio: Auxílio à Pesquisa - Programa de Pesquisa sobre Mudanças Climáticas Globais - Regular