Engineering printable composites of poly (epsilon-polycaprolactone) / beta-tricalcium phosphate for biomedical applications

Autor(es)

Goncalves Beatrice, Cesar Augusto ^[1] ; Boriolo Shimomura, Kawany Munique ^[2] ; Backes, Eduardo Henrique ^[1] ; Harb, Samarah Vargas ^[2] ; Costa, Lidiane Cristina ^{[1, 2]} ; Passador, Fabio Roberto ^[3] ; Pessan, Luiz Antonio ^{[1, 2]}

Afiliação do(s) autor(es)

^[1] Univ Fed Sao Carlos, Grad Program Mat Sci & Engn, Rodovia Washington Luiz, Km 235, BR-13565905 Sao Carlos, SP - Brazil

^[2] Univ Fed Sao Carlos, Dept Mat Engn, Rodovia Washington Luiz, Km 235, BR-13565905 Sao Carlos, SP - Brazil

^[3] Univ Fed Sao Paulo, Inst Sci & Technol, Rua Talim 330, BR-12231280 Sao Jose Dos Campos, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Polymer Composites; v. 42, n. 3 DEC 2020.
• Citações Web of Science: 0

Resumo

The incorporation of bioactive beta-tricalcium phosphate (TCP) into poly (epsilon-polycaprolactone) (PCL) originates a composite biomaterial with required properties for a variety of biomedical application. We manufactured bioactive composites of PCL/TCP by melt compounding and assessed their rheological, structural, and thermal behavior, envisioning the use of the composites as filaments for additive manufacturing via fused filament fabrication (FFF). Biocomposites of PCL with 5 wt% and 10 wt% of TCP presented similar thermal stability, crystallinity, molecular weight, and rheological behavior of neat PCL, while the addition of 25 wt% TCP leads to the formation of TCP agglomerates and increased viscosity. These results show that low concentrations of TCP in the PCL matrix make it more suitable for FFF since no change in the printing process is required. PCL/TCP filaments were fabricated by a twin-screw extruder and used to print scaffolds using FFF. The possibility to design scaffolds with specific size, geometry, and porosity enables the application of diverse types of tissue engineering. Herein, we demonstrated the feasibility of the fabrication of 3D printed PCL/TCP scaffolds for bone regeneration with improved mechanical properties and controlled geometry. (AU)

• Processo FAPESP: 17/11366-7 - Desenvolvimento de scaffolds bioinspirados de PLA/biovidros via impressão 3D
• Beneficiário: Eduardo Henrique Backes
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 18/26060-3 - Scaffolds bioativos e bactericidas para regeneração óssea via impressão 3D
• Beneficiário: Samarah Vargas Harb
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 17/09609-9 - Desenvolvimento de scaffolds bioinspirados de PLA/cargas cerâmicas bioativas via impressão 3D
• Beneficiário: Luiz Antonio Pessan
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 18/14151-4 - Desenvolvimento e caracterização de compósitos de PCL/TCP com propriedades bioativas
• Beneficiário: Kawany Munique Boriolo Shimomura
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica
• Processo FAPESP: 11/21313-1 - Estudo da cinética de reação e da adição de desativadores de metais na graftização de anidrido maleico em polipropileno, na presença e ausência de nanopartículas
• Beneficiário: Silvia Helena Prado Bettini
• Modalidade de apoio: Auxílio à Pesquisa - Regular