Cetacean Morbillivirus Infection in a Killer Whale (Orcinus orca) from Brazil

Autor(es):Mostrar menos -

Groch, Katia R. ^[1] ; Jerdy, Hassan ^[2] ; Marcondes, Milton C. C. ^[3] ; Barbosa, Lupercio A. ^[4] ; Ramos, Hernani G. C. ^[3] ; Pavanelli, Larissa ^[5] ; Fornells, Luz Alba M. G. ^[6] ; Silva, Marina B. ^[2] ; Souza, Giliane S. ^[2] ; Kanashiro, Milton M. ^[2] ; Bussad, Pollyana ^[2] ; Silveira, Leonardo S. ^[2] ; Costa-Silva, Samira ^[1] ; Wiener, Dominique J. ^[7] ; Travassos, Carlos E. P. F. ^[2] ; Catao-Dias, Jose L. ^[1] ; Diaz-Delgado, Josue ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Fac Med Vet & Zootecnia, Dept Patol, Sao Paulo - Brazil

^[2] Univ Estadual Norte Fluminense, Campos Goytacazes, Rio De Janeiro - Brazil

^[3] Inst Baleia Jubarte, Caravelas, Ba - Brazil

^[4] Inst ORCA, Vila Velha, Espirito Santo - Brazil

^[5] Inst Mamiferos Aquat, Salvador, BA - Brazil

^[6] Univ Fed Rio Janeiro, Inst Microbiol Prof Paulo de Goes, Rio De Janeiro - Brazil

^[7] Texas A&M Univ, Dept Vet Pathobiol, Coll Vet Med & Biomed Sci, College Stn, TX - USA

• Tipo de documento: Artigo Científico
• Fonte: Journal of Comparative Pathology; v. 181, p. 26-32, NOV 2020.
• Citações Web of Science: 0

Resumo

We provide pathological, immunohistochemical and molecular evidence of cetacean morbillivirus (CeMV) infection in a live-stranded adult female killer whale (Orcinus orca), which stranded alive in Esprito Santo State, Brazil, in 2014. Although attempts were made to release the animal, it stranded again and died. The main pathological findings were severe pulmonary oedema, pleural petechiation, multifocal, lymphoplasmacytic meningoencephalitis and leptomeningomyelitis with perivascular cuffing and gliosis, chronic lymphocytic bronchointerstitial pneumonia and multicentric lymph node and splenic lymphoid depletion. Other pathological findings were associated with the `live-stranding stress response'. Immunohistochemical analysis revealed multifocal morbilliviral antigen in neurons and astrocytes, and in pneumocytes, histiocytes and leukocytes in the lung. CeMV was detected by a novel reverse transcriptase polymerase chain reaction method in the brain and kidney. Phylogenetic analysis of part of the morbillivirus phosphoprotein gene indicates that the virus is similar to the Guiana dolphin (Sotalia guianensis) morbillivirus strain, known to affect cetaceans along the coast of Brazil. To the authors' knowledge, this is the first report of morbillivirus disease in killer whales. (C) 2020 Elsevier Ltd. All rights reserved. (AU)

• Processo FAPESP: 15/00735-6 - Pesquisa e caracterização da Morbilivirose em cetáceos do Brasil
• Beneficiário: Jose Luiz Catao Dias
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 15/05043-5 - Aspectos patológicos da morbilivirose e avaliação de coinfecções selecionadas em cetáceos da costa brasileira
• Beneficiário: Kátia Regina Groch
• Modalidade de apoio: Bolsas no Exterior - Estágio de Pesquisa - Pós-Doutorado
• Processo FAPESP: 17/02223-8 - Imunopatologia comparativa da infecção por Morbillivirus nos cetáceos: estudos histológico, imuno-histoquímico e molecular
• Beneficiário: Josué Díaz Delgado
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 14/24932-2 - Pesquisa e caracterização da Morbilivirose em cetáceos do Brasil
• Beneficiário: Kátia Regina Groch
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado