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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

The applicability of fingernail lead and cadmium levels as subchronic exposure biomarkers for preschool children

Texto completo
Autor(es):
Oliveira, A. S. [1] ; Costa, E. A. C. [2] ; Pereira, E. C. [1] ; Freitas, M. A. S. [3] ; Freire, B. M. [4] ; Batista, B. L. [4] ; Luz, M. S. [3] ; Olympio, K. P. K. [1]
Número total de Autores: 8
Afiliação do(s) autor(es):
[1] Univ Sao Paulo, Fac Saude Publ, Dept Saude Ambiental, Av Dr Arnaldo 715, BR-01246904 Sao Paulo, SP - Brazil
[2] Univ Fed ABC, Ctr Engn Modelagem & Ciendas Sodais Aplicadas, Ave Estados 5001, BR-09210580 Santo Andre, SP - Brazil
[3] Inst Pesquisas Tecnol Estado Sao Paulo SA, Ctr Tecnol Met & Mat, Lab Proc Met, Av Prof Almeida Prado 532, Cidade Univ, BR-05508901 Sao Paulo, SP - Brazil
[4] Univ Fed ABC, Ctr Ciencias Nat & Humanas, Ave Estados 5001, BR-09210580 Santo Andre, SP - Brazil
Número total de Afiliações: 4
Tipo de documento: Artigo Científico
Fonte: Science of The Total Environment; v. 758, MAR 1 2021.
Citações Web of Science: 0
Resumo

Preschool children are exposed daily to metals in their homes and at daycare centers (DCC). Metal exposure and health effects are associated even at low levels, and children comprise a group of public health concern. Nail metals have been studied for exposure biomonitoring and compared to other biological media. The aim of this study was to explore the applicability of preschool fingernail lead and cadmium as subchronic exposure biomarkers. Nail lead and cadmium levels (NLL and NCL) of 602 preschool children (age: 1-4 years) who attended 21 DCC in Sao Paulo, Brazil, in 2013 were analyzed. Results were compared against blood lead and cadmium levels (BLL and BCL) found in a previous study. Inductively coupled plasmamass spectrometry (ICP-MS) analyses were performed for both samples. DCC and metal contaminated sites (MCS) were georeferencing. Logistic regression tests were applied to verify associations between nail metal levels and risk factors (sex, age, maternal education, secondary smoking, DCC geographic district, vehicle flow density, relative altitude and distance between DCC and nearest MCS) (p < 0.05). BLL was stratified by exposure level (low: <5 mu g.dL(-1); high: >13.9 mu g.dL(-1); medium: >= 5 mu g.dL(-1) and <= 13.9 mu g.dL(-1)) and also tested the associations in order to verify if nail lead levels are affected by exposure intensity defined by blood metals concentrations. Radius distance and relative altitude of DCC to nearest MCS were associated with high NLL and NCL. Abnormal appearance of nails was associated with high NLL and low NCL. Lead and cadmium exposure magnitude had no significant impact on NLL. NLL should only be used for initial screening, and when financial resources are scarce, especially in areas located near contaminated sites. Preschool children were co-exposed to both lead and cadmium, reinforcing the need for broader studies evaluating exposure to environmental pollutants for more than one chemical element. (C) 2020 Elsevier B.V. All rights reserved. (AU)

Processo FAPESP: 11/13076-0 - Exposição a chumbo em São Paulo: níveis sanguíneos em pré-escolares e fatores de risco associados
Beneficiário:Kelly Polido Kaneshiro Olympio
Linha de fomento: Bolsas no Brasil - Pós-Doutorado
Processo FAPESP: 17/14392-9 - Condições de vida e trabalho dos jovens inseridos no arranjo produtivo informal e domiciliar de joias e bijuterias sob a perspectiva do expossoma
Beneficiário:Elizeu Chiodi Pereira
Linha de fomento: Bolsas no Brasil - Iniciação Científica
Processo FAPESP: 12/21840-4 - Exposição a metais não essenciais em São Paulo: níveis sanguíneos em pré-escolares e fatores de risco associados
Beneficiário:Maria Regina Alves Cardoso
Linha de fomento: Auxílio à Pesquisa - Regular
Processo FAPESP: 11/23272-0 - Exposição a chumbo em São Paulo: níveis sanguíneos em pré-escolares e fatores de risco associados
Beneficiário:Maria Regina Alves Cardoso
Linha de fomento: Auxílio à Pesquisa - Regular