Chemophenetic Significance of Anomalocalyx uleanus Metabolites Are Revealed by Dereplication Using Molecular Networking Tools

Autor(es)

de Brito, Jose Assis Gomes ^{[1, 2]} ; Pinto, Luciano da Silva ^[3] ; Chaves, Cintia Folly ^[1] ; Ribeiro da Silva, Antonio Jorge ^[1] ; da Silva, Maria Fatima das Gracas Fernandes ^[3] ; Cotinguiba, Fernando ^[1]

Afiliação do(s) autor(es)

^[1] Univ Fed Rio De Janeiro UFRJ, Inst Pesquisas Prod Nat Walter Mors, Ctr Ciencas Saude, Ave Carlos Chagas Filho, 373 Bloco H, BR-21941902 Rio De Janeiro - Brazil

^[2] Inst Fed Rondonia, Campus Ji Parana, Rua Rio Amazonas 151, BR-78960000 Ji Parana, RO - Brazil

^[3] Univ Fed Sao Carlos, Dept Quim, Rodovia Washington Luis Km 235, BR-13565905 Sao Carlos, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Molecules; v. 26, n. 4 FEB 2021.
• Citações Web of Science: 0

Resumo

Anomalocalyx uleanus (Pax \& K. Hoffm.) Ducke (Euphorbiaceae) is a singular species in the genus and is restricted and exclusive to the Brazilian Amazon. A phytochemical study of A. uleanus leaves was performed, yielding the isolation of five major compounds: catechin/epicatechin, afzelin, quercetin 3-O-alpha-L-rhamnopyranoside, and astilbin. The phytochemical compositions of the methanolic extracts of leaves, roots, bark, and stem bark were determined using a dereplication approach. Forty-six compounds were annotated from the liquid chromatography-mass spectrometry (LC-MS/MS) data, while four lipids were identified using gas chromatography-mass spectrometry (GC-MS). In total, fifty compounds were detected, and they belonged to the primary metabolism and several classes of natural products such as flavonoids, flavonoids O-glycosides, flavonoids C-glycosides, biflavonoids, procyanidin, triterpene, triterpenes esterified with phenylpropanoids, phenylpropanoid derivatives, flavonolignans, coumarins, quinic acid derivatives, and benzoic acid derivatives. This is the first report on the phytochemical data of the genus Anomalocalyx, and the results of this study will contribute to the chemosystematic knowledge of the Euphorbiaceae family and justify the need for investigation of the pharmacological potential of the species A. uleanus. (AU)

• Processo FAPESP: 15/26320-7 - Estudo químico dos fungos Erythricium salmonicolor, Diaporthe citri e a influência deles no metabolismo secundário de espécies de Citrus.
• Beneficiário: Luciano da Silva Pinto
• Modalidade de apoio: Bolsas no Brasil - Doutorado