Mathematical modelling, parameter estimation and computational simulation for skin wound healing under Copaiferalangsdorffi treatments

Autor(es)

de Oliveira, Marta H. ^{[1, 2]} ; Gushiken, Lucas F. S. ^{[1, 3]} ; Pellizzon, Claudia H. ^[1] ; Mancera, Paulo F. A. ^[1]

Afiliação do(s) autor(es)

^[1] Sao Paulo State Univ UNESP, Inst Biosci, Botucatu, SP - Brazil

^[2] Biometr Grad Program, Botucatu, SP - Brazil

^[3] Biotechnol Grad Program, Botucatu, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE; v. 199, FEB 2021.
• Citações Web of Science: 0

Resumo

We present three mathematical models which simulate the wound healing time for 10% oil-resin (10% OR), 10% hydroalcoholic extract (10% EH) (Copaifera langsdorffii drugs), Lanette cream (LC) and Collage-nase treatments. Wound healing is a complex process consisting of inflammatory, proliferative and remodelling phases. The experiments were made on rats with wounds on their backs. The mathematical models consider the interplay among neutrophils, macrophages, which play an essential role in skin wound healing, pro-inflammatory (IL-6) and anti-inflammatory (IL-10) cytokines. The ordinary differential equations (ODE) models reproduce the cellular dynamics of wound healing on the skin, suggesting levels of macrophages and neutrophils cellularity, consistent with the values of total cellularity obtained in the laboratory. The partial differential equations (PDE) model replicate the dispersion along the wound radius, suggesting that the balance of the interleukins is better modelled on copaiba-based treatments (CBT). The cell density is directly influenced by neutrophils in the wound bed and by macrophages at the wound edge. It was possible to find the time for wound healing for all treatments by inserting the diffusive terms. (C) 2020 Published by Elsevier B.V. (AU)

• Processo FAPESP: 14/23684-5 - Avaliação dos mecanismos celulares e moleculares na cicatrização de lesões cutâneas utilizando cremes à base de extrato hidroalcoólico e óleo-resina de Copaifera langsdorffii
• Beneficiário: Lucas Fernando Sérgio Gushiken
• Modalidade de apoio: Bolsas no Brasil - Mestrado
• Processo FAPESP: 11/13630-7 - Validação química e farmacológica de extratos e princípios ativos de espécies de Copaifera
• Beneficiário: Jairo Kenupp Bastos
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 17/17600-1 - "Avaliação do potencial cicatricial de formulações tópicas contendo terpenos em lesões cutâneas de ratos"
• Beneficiário: Claudia Helena Pellizzon
• Modalidade de apoio: Auxílio à Pesquisa - Regular