Elaboration and mechanical properties of elastomeric fibrous scaffolds based on crosslinked poly(glycerol sebacate) and cyclodextrin for soft tissue engineering

Autor(es)

Flaig, Florence ^[1] ; Faria Bellani, Caroline ^[1] ; Uyumaz, Ozgun ^[1] ; Schlatter, Guy ^[1] ; Hebraud, Anne ^[1]

Afiliação do(s) autor(es)

^[1] Univ Strasbourg, ICPEES, CNRS, UMR 7515, 25 Rue Becquerel, F-67087 Strasbourg 2 - France

• Tipo de documento: Artigo Científico
• Fonte: MATERIALS ADVANCES; v. 2, n. 4, p. 1284-1293, FEB 21 2021.
• Citações Web of Science: 1

Resumo

Poly(glycerol sebacate) (PGS) is a promising material designed for soft tissue engineering. Several examples of its use to prepare electrospun scaffolds can be found in the literature. However, the fabrication of nanofibrous scaffolds based on crosslinked PGS remains challenging because of its thermoset nature. Here, we propose a new method to electrospin PGS in blend with polyvinylpyrrolidone (PVP) and hydroxypropyl-beta-cyclodextrin (HP beta CD) as carrier molecules. After electrospinning, the PGS prepolymers were crosslinked by thermal treatment under vacuum, resulting in elastomeric fibers. Finally, unreacted molecules were removed by immersion of the fibers in water. Our PGS/HP beta CD-based nanofibrous scaffolds are good candidates for soft tissue engineering with a Young's modulus of 2 MPa and strain at break of 390% in the dry state, reaching 120 to 170 kPa and 70% in the wet state. (AU)

• Processo FAPESP: 16/04418-8 - Enxertos vasculares tubulares obtidos por eletrofiação para vascularização rápida de construtos para engenharia tecidual óssea
• Beneficiário: Caroline Faria Bellani
• Modalidade de apoio: Bolsas no Exterior - Estágio de Pesquisa - Doutorado Direto
• Processo FAPESP: 14/17939-0 - Desenvolvimento de scaffolds de poli(caprolactona) incorporados com biosilicato e nanocristais de celulose para Engenharia de Tecidos e regeneração óssea
• Beneficiário: Caroline Faria Bellani
• Modalidade de apoio: Bolsas no Brasil - Doutorado Direto