Latanoprost-loaded phytantriol cubosomes for the treatment of glaucoma

Autor(es)

Del Valle Bessone, Carolina ^{[1, 2]} ; Akhlaghi, Seyedeh Parinaz ^[3] ; Ignacio Tartara, Luis ^{[1, 2]} ; Quinteros, Daniela Alejandra ^{[1, 2]} ; Loh, Watson ^[3] ; Alberto Allemandi, Daniel ^{[1, 2]}

Afiliação do(s) autor(es)

^[1] Univ Nacl Cordoba, CONICET, Unidad Invest & Desarrollo Tecnol Farmaceut UNITE, Ciudad Univ, RA-5000 Cordoba - Argentina

^[2] Univ Nacl Cordoba, Fac Ciencias Quim, Dept Ciencias Farmaceut, Ciudad Univ, RA-5000 Cordoba - Argentina

^[3] Univ Campinas UNICAMP, Inst Chem, POB 6154, BR-13083970 Campinas, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: European Journal of Pharmaceutical Sciences; v. 160, MAY 1 2021.
• Citações Web of Science: 0

Resumo

Glaucoma is a degenerative optic neuropathy characterized by increased intraocular pressure that if untreated can result in blindness. Ophthalmological drug therapy is a challenge of great clinical importance due to the diversity of ocular biological barriers which commonly causes limited or no effectiveness for drugs delivered through the eye. In this work, we proposed the development of nanosized cubic liquid crystals (cubosomes) as a new drug carrier system for latanoprost, an anti-glaucoma drug. Latanopmst-loaded phytantriol cubosomes (CubLnp) were prepared using a top-down method. Latanopmst concentration in the formulations ranged from 0.00125% to 0.02% w/v. All cubosomes displayed an average size around 200 nm, a low polydispersity index of 0.1 and zeta potential values around -25 mV, with an encapsulation efficiency of about 90%. Structural studies revealed that cubosomes displayed a double-diamond surface, Pn3m cubic-phase structure, and was not affected by drug loading. Calorimetric studies revealed a fast and exothermic interaction between latanoprost and cubosomes. According to in vitro essays, latanoprost release from cubosomes was slow in time, evidencing a sustained release profile. Based on this behavior, the in vivo hypotensive intraocular effect was evaluated by means of the subconjunctival administration of CubLnp in normotensive rabbits. We obtained promising results in comparison with a marketed latanoprost formulation (0.005% w/v). (AU)

• Processo FAPESP: 16/50455-2 - Latanoprost loaded phytantriol cubosomes for glaucoma treatment
• Beneficiário: Watson Loh
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 14/24305-8 - Máscaras de Celulose Bacteriana Carregadas com Cubossomas contendo o Peptídeo Pal-KTTKS: Um Sistema Multifuncional de Cuidados com a Pele
• Beneficiário: Seyedeh Parinaz Akhlaghi
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado