Preliminary evidence of acylated ghrelin association with depression severity in postmenopausal women

Autor(es)

Naufel, Maria Fernanda ^[1] ; Pedroso, Amanda Paula ^[1] ; Oyama, Lila Missae ^[1] ; Telles, Monica Marques ^[1] ; Hachul, Helena ^{[2, 3]} ; Ribeiro, Eliane Beraldi ^[1]

Afiliação do(s) autor(es)

^[1] Univ Fed Sao Paulo UNIFESP, Dept Physiol, Rua Botucatu 862, BR-04023062 Sao Paulo, SP - Brazil

^[2] Univ Fed Sao Paulo UNIFESP, Dept Psychobiol, Sao Paulo, SP - Brazil

^[3] Univ Fed Sao Paulo UNIFESP, Dept Gynecol, Sao Paulo, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: SCIENTIFIC REPORTS; v. 11, n. 1 MAR 5 2021.
• Citações Web of Science: 0

Resumo

We have previously shown increased depression and anxiety scores in postmenopausal overweight women, when compared to overweight premenopausal women. The mechanisms responsible for these alterations are not understood. Although ghrelin involvement in mood modulation has been suggested, its role is still ambiguous and has not been evaluated in postmenopause. Here we investigated the association of ghrelin with depression and anxiety symptoms in postmenopausal women. Fifty-five postmenopausal women with depression symptoms, who were not in use of hormones or antidepressants, were included in the study. Depression symptoms were evaluated by Beck's Depression Inventory (BDI) and Patient Health Questionnaire-9 (PHQ-9) and anxiety symptoms were evaluated by Beck's Anxiety Inventory (BAI). Women were allocated into three groups, according to BDI classification of mild, moderate, or severe depression symptoms. Anthropometric, biochemical and hormonal parameters were analyzed. Total and acylated ghrelin levels were higher in the severe depression than in the mild depression group. Multivariate regression analyses showed positive associations of BDI scores with acylated ghrelin and BMI, and of PHQ-9 scores with acylated ghrelin and homeostasis model assessment of insulin resistance (HOMA-IR). BAI scores associated positively with waist-to-hip ratio. To the best of our knowledge, this is the first demonstration of an association between acylated ghrelin and the severity of depression symptoms in postmenopausal women. This association may reflect either a physiological response aimed at fighting against depression symptoms or a causal factor of this mental disorder. (AU)

• Processo FAPESP: 12/03172-4 - Obesidade e depressão na pós-menopausa: estudo em ratas dos efeitos da ovariectomia sobre aspectos comportamentais e da regulação central da ingestão alimentar
• Beneficiário: Eliane Beraldi Ribeiro
• Modalidade de apoio: Auxílio à Pesquisa - Regular