Aluminum bioconcentration in female Nile tilapia Oreochromis niloticus (Perciformes: Cichlidae) and the effects on pituitary gonadotropins

Autor(es)

Narcizo, Amanda de Moraes ^[1] ; Correia, Tiago Gabriel ^[1] ; Bianchini, Adalto ^[2] ; Mayer, Mario Gustavo ^[3] ; Zampieri, Ricardo Andrade ^[1] ; Floeter-Winter, Lucile Maria ^[1] ; Moreira, Renata Guimaraes ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Inst Biociencias, R Matao, Trav 14 321, BR-05508090 Sao Paulo, SP - Brazil

^[2] Univ Fed Rio Grande, Inst Ciencias Biolag, Av Italia Km 8, Campus Carreiros, BR-96201900 Rio Grande, RS - Brazil

^[3] Inst Butantan, Lab Genet, Div Biol, Av Vital Brazil 1500, BR-05503900 Sao Paulo, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY; v. 241, MAR 2021.
• Citações Web of Science: 0

Resumo

In this study, we measured aluminum (Al) bioconcentration in the brain, ovaries, and liver of Oreochromis niloticus females, and analyzed the effects of exposure to Al and acidic pH on the gene expression of follicle stimulating hormone (beta fsh) and luteinizing hormone (beta lh) in these animals. Mature females were divided into 4 groups, thus being maintained for 96 h in one of the following conditions: control at neutral pH (Ctr); Al at neutral pH (Al); acidic pH (Ac), and Al at acidic pH (Al-Ac). pH alone did not influence Al bioconcentration in the brain. The animals from the Al-Ac group bioconcentrated more Al in the ovaries than those from the Al group, while no differences were observed in the liver. Aluminum bioconcentration was higher in the brain than in the liver and ovaries in Al-exposed animals (Al and Al-Ac), and higher in the brain than in the ovaries in the Ctr and Ac groups. The liver bioconcentrates more Al than the ovaries in the females from the Ctr and Ac groups. Aluminum and/or acidic pH did not alter beta fsh gene expression, while beta lh gene expression decreased in females from the Al group. Aluminum acted as an endocrine disruptor, suggesting deleterious effects in reproduction that could result in ovulation failure. Aluminum can act directly and/or indirectly in the pituitary, affecting ovarian steroidogenesis and altering the reproductive endocrine axis of mature O. niloticus females in an acute period of exposure. (AU)

• Processo FAPESP: 06/50920-5 - Influência do alumínio e do pH ácido sobre a fisiologia reprodutiva de peixes teleósteos
• Beneficiário: Renata Guimarães Moreira Whitton
• Modalidade de apoio: Auxílio à Pesquisa - Regular