Three-dimensional printed poly (L-lactide) and hydroxyapatite composite for reconstruction of critical bone defect in rabbits

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Minto, Bruno Watanabe ^{[1, 2]} ; Sprada, Aricia Gomes ^{[2, 3]} ; Goncalves Neto, Jose Aloizio ^{[2, 4]} ; de Alcantara, Brenda Mendonca ^{[2, 4]} ; de Sa Rocha, Thiago Andre Salvitti ^{[2, 5]} ; Valentim Hespanha, Ana Carolina ^{[2, 4]} ; Quarterone, Carolina ^{[2, 6]} ; Sartori, Maressa da Rocha ^{[2, 7]} ; Hataka, Alessandre ^{[2, 8]} ; Ramirez Uscategui, Ricardo Andres ^{[2, 9]} ; Gosuen Goncalves Dias, Luis Gustavo ^{[1, 2]}

Afiliação do(s) autor(es)

^[1] Univ Estadual Paulista, Fac Agr & Vet Sci, Dept Clin & Vet Surg, Jaboticabal, SP - Brazil

^[2] Univ Estadual Paulista Julio de Mesquita Filho UN, Fac Agr & Vet Sci, Dept Clin & Vet Surg, Jaboticabal, SP - Brazil

^[3] Ctr Univ Maringa, Dept Vet Anat, Maringa, Parana - Brazil

^[4] Univ Estadual Paulista, Fac Agr & Vet Sci, Grad Program Vet Surg, Jaboticabal, SP - Brazil

^[5] Univ Brasil, Dept Clin & Vet Surg, Descalvado, SP - Brazil

^[6] Ctr Univ Maringa, Dept Vet Surg, Maringa, Parana - Brazil

^[7] Ctr Univ Maringa, Maringa, Parana - Brazil

^[8] Univ Estadual Paulista, Fac Agr & Vet Sci, Dept Vet Clin Sci, Botucatu, SP - Brazil

^[9] Univ Fed Vales Jequitinhonha & Mucuri, Inst Sci, Dept Vet Clin Sci, Unai, MG - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Acta Cirurgica Brasileira; v. 36, n. 4 2021.
• Citações Web of Science: 0

Resumo

ABSTRACT Purpose To use a 3D printed poly (L-lactide) acid (PLLA) and hydroxyapatite (HA) composite as a bone substitute for reconstruction of a critical bone defect in the radius of rabbits. Methods A 1.5 cm ostectomy was performed in the radial diaphysis of 60 New Zealand white rabbits. The rabbits were divided into three groups according to surgical treatment of the bone defect (group I – control, group II – bone graft, group III – 3D PLLA). Each group was divided into four subgroups with different radiographic and histopathologic evaluation times (T1 – 15 days, T2 – 30 days, T3 – 60 days, T4 – 90 days). Results The implant group had greater clinically lameness (p = 0.02), edema (p = 0.007), pain (p = 0.04) and more complications at the surgical site (p = 0.03). Histologically, this group showed greater congestion (p = 0.04), hemorrhage (p = 0.04) and inflammation. Osteogenesis was microscopically similar between days (p = 0.54) and treatments (p = 0.17), even though radiographically, more effective bone healing occurred in the graft group (II), with more callus and bone bridge formation. Conclusions The customization of a 3D PLLA/HA scaffold was successful. However, in animals receiving the polymer-ceramic composite less bone callus and bone bridge was formed compared to the graft group. (AU)

• Processo FAPESP: 15/10139-1 - Impressão tridimensional de substituto ósseo na reconstrução de falha segmental em rádio de coelhos
• Beneficiário: Arícia Gomes Sprada
• Modalidade de apoio: Bolsas no Brasil - Doutorado