| Texto completo | |
| Autor(es): Mostrar menos - |
Damasceno, Luana
[1]
;
Terzian, Ana Carolina B.
[2]
;
Fuller, Trevon
[1]
;
Estofolete, Cassia F.
[3]
;
Andrade, Adriana
[4]
;
Kroon, Erna G.
[4]
;
Zin, Andrea A.
[5]
;
Vasconcelos, Zilton
[5]
;
Pereira, Jr., Jose P.
[5]
;
Castilho, Marcia C.
[6]
;
Piaulino, Isa Cristina R.
[7]
;
Vasilakis, Nikos
[8]
;
Moreira, Maria E.
[5]
;
Nielsen-Saines, Karin
[9]
;
Espinosa, Flor E. Martinez
[10, 11]
;
Nogueira, Mauricio L.
[3]
;
Brasil, Patricia
[1]
Número total de Autores: 17
|
| Afiliação do(s) autor(es): Mostrar menos - | [1] Oswaldo Cruz Fdn OCRUZ, Natl Inst Infect Dis, Acute Febrile Illnesses Lab, BR-21040900 Rio De Janeiro, RJ - Brazil
[2] Oswaldo Cruz Fdn FIOCRUZ Minas, Rene Rachou Inst, BR-30190002 Belo Horizonte, MG - Brazil
[3] Sch Med FAMERP, Lab Virol, BR-15090000 Sao Jose Do Rio Preto, SP - Brazil
[4] Fed Univ Minas Gerais UFMG, Inst Biol Sci, BR-31270901 Pampulha Belo Horizonte, MG - Brazil
[5] Oswaldo Cruz Fdn FIOCRUZ, Fernandes Figueira Inst, BR-22250020 Rio De Janeiro, RJ - Brazil
[6] Dr Heitor Vieira Dourado Trop Med Fdn, Dept Virol, BR-69040000 Manaus, AM - Brazil
[7] Amazonas State Univ, Postgrad Program Trop Med, BR-69040000 Manaus, AM - Brazil
[8] Univ Texas Med Branch, Dept Pathol, Galveston, TX 77555 - USA
[9] Univ Calif Los Angeles, David Geffen Sch Med, Dept Pediat, Los Angeles, CA 90095 - USA
[10] Oswaldo Cruz Fdn FIOCRUZ Amazonia, Leonidas & Maria Deane Inst, Lab Terr Environm Hlth & Sustainabil, BR-69057070 Manaus, AM - Brazil
[11] Dr Heitor Vieira Dourado Trop Med Fdn, Dept Malaria, BR-69040000 Manaus, AM - Brazil
Número total de Afiliações: 11
|
| Tipo de documento: | Artigo Científico |
| Fonte: | Viruses-Basel; v. 13, n. 5 MAY 2021. |
| Citações Web of Science: | 0 |
| Resumo | |
The Zika virus (ZIKV) epidemic in Brazil occurred in regions where dengue viruses (DENV) are historically endemic. We investigated the differences in adverse pregnancy/infant outcomes in two cohorts comprising 114 pregnant women with PCR-confirmed ZIKV infection in Rio de Janeiro, Southeastern Brazil (n = 50) and Manaus, in the north region of the country (n = 64). Prior exposure to DENV was evaluated through plaque reduction neutralizing antibody assays (PRNT 80) and DENV IgG serologies. Potential associations between pregnancy outcomes and Zika attack rates in the two cities were explored. Overall, 31 women (27%) had adverse pregnancy/infant outcomes, 27 in Rio (54%) and 4 in Manaus (6%), p < 0.001. This included 4 pregnancy losses (13%) and 27 infants with abnormalities at birth (24%). A total of 93 women (82%) had evidence of prior DENV exposure, 45 in Rio (90%) and 48 in Manaus (75%). Zika attack rates differed; the rate in Rio was 10.28 cases/10,000 and in Manaus, 0.6 cases/10,000, p < 0.001. Only Zika attack rates (Odds Ratio: 17.6, 95% Confidence Interval 5.6-55.9, p < 0.001) and infection in the first trimester of pregnancy (OR: 4.26, 95% CI 1.4-12.9, p = 0.011) were associated with adverse pregnancy and infant outcomes. Pre-existing immunity to DENV was not associated with outcomes (normal or abnormal) in patients with ZIKV infection during pregnancy. (AU) | |
| Processo FAPESP: | 13/21719-3 - Estudo epidemiológico da dengue (sorotipos 1 a 4) em coorte prospectiva de São José do Rio Preto, São Paulo, Brasil, durante 2014 a 2018 |
| Beneficiário: | Maurício Lacerda Nogueira |
| Modalidade de apoio: | Auxílio à Pesquisa - Temático |
| Processo FAPESP: | 15/12295-0 - Diagnóstico de arboviroses brasileiras e emergentes em pacientes e mosquitos em duas regiões distintas do Brasil |
| Beneficiário: | Ana Carolina Bernardes Terzian |
| Modalidade de apoio: | Bolsas no Brasil - Pós-Doutorado |
| Processo FAPESP: | 16/15021-1 - Estudo clínico-epidemiológico em coorte prospectiva de gestantes infectadas pelo vírus Zika em São José do Rio Preto |
| Beneficiário: | Maurício Lacerda Nogueira |
| Modalidade de apoio: | Auxílio à Pesquisa - Pesquisa em Políticas Públicas para o SUS |