Aerobic exercise and inspiratory muscle training increase functional capacity in patients with univentricular physiology after Fontan operation: A randomized controlled trial

Autor(es):Mostrar menos -

Ribeiro Turquetto, Aida Luiza ^[1] ; dos Santos, Marcelo Rodrigues ^[1] ; Agostinho, Daniela Regina ^[1] ; Carrari Sayegh, Ana Luiza ^[2] ; de Souza, Francis Ribeiro ^[1] ; Amato, Luciana Patrick ^[1] ; Ru Barnabe, Milena Schiezari ^[1] ; de Oliveira, Patricia Alves ^[1] ; Liberato, Gabriela ^[1] ; Binotto, Maria Angelica ^[1] ; Negrao, Carlos Eduardo ^{[3, 1]} ; Caneo, Luiz Fernando ^[1] ; Trindade, Evelinda ^[1] ; Jatene, Fabio Biscegli ^[1] ; Jatene, Marcelo Biscegli ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Heart Inst, Med Sch, Sao Paulo - Brazil

^[2] Univ Auckland, Auckland - New Zealand

^[3] Univ Sao Paulo, Sch Phys Educ & Sport, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: INTERNATIONAL JOURNAL OF CARDIOLOGY; v. 330, p. 50-58, MAY 1 2021.
• Citações Web of Science: 0

Resumo

Background: The effect of exercise training and its mechanisms on the functional capacity improvement in Fontan patients (FP) are virtually unknown. This trial evaluated four-month aerobic exercise training and inspiratory muscle training on functional capacity, pulmonary function, and autonomic control in patients after Fontan operation. Methods: A randomized controlled clinical trial with 42 FP aged 12 to 30 years and, at least, five years of Fontan completion. Twenty-seven were referred to a four-months supervised and personalized aerobic exercise training (AET) or an inspiratory muscle training (IMT). A group of non-exercise (NET) was used as control. The effects of the exercise training in peak VO2; pulmonary volumes and capacities, maximal inspiratory pressure (MIP); muscle sympathetic nerve activity (MSNA); forearm blood flow (FBF); handgrip strength and cross-sectional area of the thigh were analyzed. Results: The AET decreased MSNA (p = 0.042), increased FBF (p 0.012) and handgrip strength (p = 0.017). No significant changes in autonomic control were found in IMT and NET groups. Both AET and IMT increased peak VO2, but the increase was higher in the AET group compared to IMT (23% vs. 9%). No difference was found in the NET group. IMT group showed a 58% increase in MIP (p = 0.008) in forced vital capacity (p = 0.011) and forced expiratory volume in the first second (p = 0.011). No difference in pulmonary function was found in the AET group. Conclusions: Both aerobic exercise and inspiratory musde training improved functional capacity. The AET group developed autonomic control, and handgrip strength, and the IMT increased inspiratory muscle strength and spirometry. (C) 2021 Elsevier B.V. All rights reserved. (AU)

• Processo FAPESP: 12/05252-5 - Avaliação cardiovascular, pulmonar e músculo esquelética em pacientes com fisiologia univentricular no período pós-operatório tardio da cirurgia de Fontan: efeitos do treinamento físico
• Beneficiário: Marcelo Biscegli Jatene
• Modalidade de apoio: Auxílio à Pesquisa - Regular