Recent Advances in Immunosafety and Nanoinformatics of Two-Dimensional Materials Applied to Nano-imaging

Autor(es)

Da Silva, Gabriela H. ^[1] ; Franqui, Lidiane S. ^{[2, 1]} ; Petry, Romana ^{[1, 3]} ; Maia, Marcella T. ^[1] ; Fonseca, Leandro C. ^[4] ; Fazzio, Adalberto ^{[1, 3]} ; Alves, Oswaldo L. ^{[1, 4]} ; Martinez, Diego Stefani T. ^{[2, 1]}

Afiliação do(s) autor(es)

^[1] Brazilian Ctr Res Energy & Mat CNPEM, Brazilian Nanotechnol Natl Lab LNNano, Campinas - Brazil

^[2] Univ Campinas UNICAMP, Sch Technol, Limeira - Brazil

^[3] Fed Univ ABC UFABC, Ctr Nat & Human Sci, Santo Andre - Brazil

^[4] Univ Campinas Unicamp, NanoBioss Lab & Solid State Chem Lab LQES, Inst Chem, Campinas - Brazil

• Tipo de documento: Artigo de Revisão
• Fonte: FRONTIERS IN IMMUNOLOGY; v. 12, JUN 3 2021.
• Citações Web of Science: 0

Resumo

Two-dimensional (2D) materials have emerged as an important class of nanomaterials for technological innovation due to their remarkable physicochemical properties, including sheet-like morphology and minimal thickness, high surface area, tuneable chemical composition, and surface functionalization. These materials are being proposed for new applications in energy, health, and the environment; these are all strategic society sectors toward sustainable development. Specifically, 2D materials for nano-imaging have shown exciting opportunities in in vitro and in vivo models, providing novel molecular imaging techniques such as computed tomography, magnetic resonance imaging, fluorescence and luminescence optical imaging and others. Therefore, given the growing interest in 2D materials, it is mandatory to evaluate their impact on the immune system in a broader sense, because it is responsible for detecting and eliminating foreign agents in living organisms. This mini-review presents an overview on the frontier of research involving 2D materials applications, nano-imaging and their immunosafety aspects. Finally, we highlight the importance of nanoinformatics approaches and computational modeling for a deeper understanding of the links between nanomaterial physicochemical properties and biological responses (immunotoxicity/biocompatibility) towards enabling immunosafety-by-design 2D materials. (AU)

• Processo FAPESP: 18/25103-0 - Interfaces - grafenos funcionalizados e poluentes orgânicos: uma abordagem teórica-experimental em nanotecnologia ambiental
• Beneficiário: Romana Petry
• Modalidade de apoio: Bolsas no Brasil - Doutorado Direto
• Processo FAPESP: 17/02317-2 - Interfaces em materiais: propriedades eletrônicas, magnéticas, estruturais e de transporte
• Beneficiário: Adalberto Fazzio
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 14/50906-9 - INCT 2014: em Materiais Complexos Funcionais (INOMAT)
• Beneficiário: Fernando Galembeck
• Modalidade de apoio: Auxílio à Pesquisa - Temático