Recent Advances in Immunosafety and Nanoinformatics of Two-Dimensional Materials Applied to Nano-imaging

Author(s)

Da Silva, Gabriela H. ^[1] ; Franqui, Lidiane S. ^{[2, 1]} ; Petry, Romana ^{[1, 3]} ; Maia, Marcella T. ^[1] ; Fonseca, Leandro C. ^[4] ; Fazzio, Adalberto ^{[1, 3]} ; Alves, Oswaldo L. ^{[1, 4]} ; Martinez, Diego Stefani T. ^{[2, 1]}

Affiliation

^[1] Brazilian Ctr Res Energy & Mat CNPEM, Brazilian Nanotechnol Natl Lab LNNano, Campinas - Brazil

^[2] Univ Campinas UNICAMP, Sch Technol, Limeira - Brazil

^[3] Fed Univ ABC UFABC, Ctr Nat & Human Sci, Santo Andre - Brazil

^[4] Univ Campinas Unicamp, NanoBioss Lab & Solid State Chem Lab LQES, Inst Chem, Campinas - Brazil

• Document type: Review article
• Source: FRONTIERS IN IMMUNOLOGY; v. 12, JUN 3 2021.
• Web of Science Citations: 0

Abstract

Two-dimensional (2D) materials have emerged as an important class of nanomaterials for technological innovation due to their remarkable physicochemical properties, including sheet-like morphology and minimal thickness, high surface area, tuneable chemical composition, and surface functionalization. These materials are being proposed for new applications in energy, health, and the environment; these are all strategic society sectors toward sustainable development. Specifically, 2D materials for nano-imaging have shown exciting opportunities in in vitro and in vivo models, providing novel molecular imaging techniques such as computed tomography, magnetic resonance imaging, fluorescence and luminescence optical imaging and others. Therefore, given the growing interest in 2D materials, it is mandatory to evaluate their impact on the immune system in a broader sense, because it is responsible for detecting and eliminating foreign agents in living organisms. This mini-review presents an overview on the frontier of research involving 2D materials applications, nano-imaging and their immunosafety aspects. Finally, we highlight the importance of nanoinformatics approaches and computational modeling for a deeper understanding of the links between nanomaterial physicochemical properties and biological responses (immunotoxicity/biocompatibility) towards enabling immunosafety-by-design 2D materials. (AU)

• FAPESP's process: 18/25103-0 - Interfaces - functionalized graphenes and organic pollutans: theoretical-experimental approach in environmental nanotechnology
• Grantee: Romana Petry
• Support Opportunities: Scholarships in Brazil - Doctorate (Direct)
• FAPESP's process: 17/02317-2 - Interfaces in materials: electronic, magnetic, structural and transport properties
• Grantee: Adalberto Fazzio
• Support Opportunities: Research Projects - Thematic Grants
• FAPESP's process: 14/50906-9 - INCT 2014: in Functional Complex Materials
• Grantee: Fernando Galembeck
• Support Opportunities: Research Projects - Thematic Grants