Skeletal muscle heme oxygenase-1 activity regulates aerobic capacity

Autor(es):Mostrar menos -

de Souza, Rodrigo W. Alves ^[1] ; Gallo, David ^[1] ; Lee, Ghee Rye ^[1] ; Katsuyama, Eri ^[2] ; Schaufler, Alexa ^[1] ; Weber, Janick ^[1] ; Csizmadia, Eva ^[1] ; Tsokos, George C. ^[2] ; Koch, Lauren G. ^[3] ; Britton, Steven L. ^{[4, 5]} ; Wisloff, Ulrik ^[6] ; Brum, Patricia C. ^[7] ; Otterbein, Leo E. ^[1]

Afiliação do(s) autor(es)

^[1] Harvard Med Sch, Beth Israel Deaconess Med Ctr, Dept Surg, Boston, MA 02115 - USA

^[2] Harvard Med Sch, Beth Israel Deaconess Med Ctr, Dept Med, Boston, MA 02115 - USA

^[3] Univ Toledo, Dept Physiol & Pharmacol, Toledo, OH 43606 - USA

^[4] Univ Michigan, Dept Mol & Integrat Physiol, Ann Arbor, MI 48109 - USA

^[5] Univ Michigan, Dept Anesthesiol, Ann Arbor, MI 48109 - USA

^[6] Norwegian Univ Sci & Technol, KG Jebsen Ctr Exercise Med, Dept Circulat & Med Imaging, N-7491 Trondheim - Norway

^[7] Univ Sao Paulo, Sch Phys Educ & Sport, BR-05508030 Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: CELL REPORTS; v. 35, n. 3 APR 20 2021.
• Citações Web of Science: 0

Resumo

Physical exercise has profound effects on quality of life and susceptibility to chronic disease; however, the regulation of skeletal muscle function at the molecular level after exercise remains unclear. We tested the hypothesis that the benefits of exercise on muscle function are linked partly to microtraumatic events that result in accumulation of circulating heme. Effective metabolism of heme is controlled by Heme Oxygenase-1 (HO-1, Hmox1), and we find that mouse skeletal muscle-specific HO-1 deletion (Tam-Cre-HSA-Hmox1(fl/fl)) shifts the proportion of muscle fibers from type IIA to type IIB concomitant with a disruption in mitochondrial content and function. In addition to a significant impairment in running performance and response to exercise training, Tam-Cre-HSA-Hmox1(fl/fl) mice show remarkable muscle atrophy compared to Hmox1(fl/fl) controls. Collectively, these data define a role for heme and HO-1 as central regulators in the physiologic response of skeletal muscle to exercise. (AU)

• Processo FAPESP: 14/25957-9 - Influência da aptidão aeróbica na homeostase redox: identificação e implicação biológica da oxidação de resíduos cisteína em proteínas do músculo cardíaco e esquelético
• Beneficiário: Rodrigo Wagner Alves de Souza
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 17/19954-5 - Hemopexina e Heme Oxigenase-1 no Músculo Esquelético: contribuição na melhora da capacidade aeróbica
• Beneficiário: Rodrigo Wagner Alves de Souza
• Modalidade de apoio: Bolsas no Exterior - Estágio de Pesquisa - Pós-Doutorado