Multifocal Analysis of Acute Pain After Third Molar Removal

Autor(es):Mostrar menos -

Weckwerth, Giovana Maria ^[1] ; Dionisio, Thiago Jose ^[1] ; Costa, Yuri Martins ^[2] ; Zupelari-Goncalves, Paulo ^[1] ; Oliveira, Gabriela Moraes ^[1] ; Torres, Elza Araujo ^[1] ; Bonjardim, Leonardo Rigoldi ^[1] ; Faria, Flavio Augusto Cardoso ^[1] ; Calvo, Adriana Maria ^[1] ; Moore, Troy ^[3] ; Absher, Devin Michael ^[4] ; Santos, Carlos Ferreira ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Bauru Sch Dent, Dept Biol Sci, Bauru, SP - Brazil

^[2] Univ Estadual Campinas, Piracicaba Dent Sch, Dept Biosci, Piracicaba - Brazil

^[3] Kailos Genet Inc, HudsonAlpha Inst Biotechnol, Huntsville, AL - USA

^[4] HudsonAlpha Inst Biotechnol, Huntsville, AL - USA

• Tipo de documento: Artigo Científico
• Fonte: FRONTIERS IN PHARMACOLOGY; v. 12, APR 15 2021.
• Citações Web of Science: 0

Resumo

Background: To analyze the pain modulation capacity profile in a Brazilian population, the relationship between opioid receptor (OPRM1) and Catechol-O-methyltransferase (COMT) 1polymorphisms and pain modulation capacity was determined through preoperative pain modulation tests and acute postoperative pain control evaluation, swelling, and trismus in 200 volunteers undergoing lower third molar removal. Methods: Psychologic and clinical parameters were measured. Patient DNA was sequenced for single nucleotide polymorphisms in OPRM1 and COMT, and the salivary concentration of interleukin (IL)-2 (IL)-6, interferon (IFN)-gamma and tumor necrosis factor (TNF)-alpha was evaluated. Primary outcomes were the influence of all predictors on the fluctuation of pain intensity using a visual analogue scale (VAS), and swelling and trismus on the 2nd and 7th postoperative days. Preoperative pain modulation capacity (CPM), pain catastrophizing scale (PCS), body mass index (BMI), and surgery duration and difficulty were evaluated. Results: Salivary concentration of IFN-gamma and IL-2 as well as the duration of surgery influenced the fluctuation of postoperative pain in the VAS, and in the sum of the differences in pain intensity test at 8, 48, and 96 h. BMI influenced swelling, while both BMI and COMT haplotype influenced trismus on the 2nd postoperative day. Conclusion: Polymorphisms in COMT, salivary concentrations of IL-2 and IFN-gamma, BMI, and duration of surgery were predictors for pain fluctuation, swelling, and trismus on the 2nd day after lower third molar extraction. This therapy was effective in controlling inflammatory symptomatology after lower third molar extraction and ibuprofen was well tolerated by patients. (AU)

• Processo FAPESP: 17/12725-0 - Modelo de farmacocinética/farmacodinâmica (PK/PD) na influência do polimorfismo genético do P450 (CYP2C9) de anti-inflamatórios não esteroidais e metabólitos principais a partir de amostras de saliva por LCMS/MS e seu papel na personalização da prescrição
• Beneficiário: Adriana Maria Calvo
• Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores
• Processo FAPESP: 18/04157-5 - Farmacogenética clínica dos enantiômeros do ibuprofeno após exodontias de terceiros molares inferiores
• Beneficiário: Giovana Maria Weckwerth
• Modalidade de apoio: Bolsas no Exterior - Estágio de Pesquisa - Doutorado