A systematic review and meta-analysis of the effect of photodynamic therapy for the treatment of oral mucositis

Autor(es)

de Oliveira, Analu Barros ^[1] ; Ferrisse, Tulio Morandin ^[2] ; Basso, Fernanda Goncalves ^[3] ; Fontana, Carla Raquel ^[4] ; Aparecida Giro, Elisa Maria ^[1] ; Brighenti, Fernanda Lourencao ^[1]

Afiliação do(s) autor(es)

^[1] Sao Paulo State Univ, Sch Dent, Dept Morphol Genet Orthodont & Pediat Dent, UNESP, Araraquara, SP - Brazil

^[2] Sao Paulo State Univ, Sch Dent, UNESP, Dept Dent Mat & Prosthesis, Araraquara, SP - Brazil

^[3] Univ Ribeirao Preto, UNAERP, Dept Dent, Ribeirao Preto, SP - Brazil

^[4] Sao Paulo State Univ, Sch Pharmaceut Sci, Dept Clin Anal, UNESP, Araraquara, SP - Brazil

• Tipo de documento: Artigo de Revisão
• Fonte: Photodiagnosis and Photodynamic Therapy; v. 34, JUN 2021.
• Citações Web of Science: 0

Resumo

Background: Oral mucositis is a significant reaction to antineoplastic treatment characterized with pain, nutritional compromise, impact on the quality of life, interruption in cancer therapy and risk for infection. There is no effective standard protocol for the treatment of oral mucositis. This study aims to synthesize the scientific evidence available about the effects of photodynamic therapy on treatment of oral mucositis. Methods: PubMed, Scopus, Web of Science, Science Direct, Scielo, Embase and Cochrane libraries were searched. Two independent and calibrated researchers (kappa = 0.92) performed all systematic steps according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). To access the risk of bias, RoB 2 and Delphi list criteria for clinical trials were used. Meta-analysis was conducted using the R software with ``META{''} package. Results: Clinical and randomized clinical trials were included with a total of five articles. Meta-analysis, level of evidence, and risk of bias assessment were performed showing that photodynamic therapy was effective in reducing healing time in association with low-power laser therapy when compared to low-power laser therapy alone (p = 0.0005). Conclusion: Photodynamic therapy presents promising results for the treatment of oral mucositis. It may be an effective therapeutic option, contributing to the healing of injured tissues especially in the time needed for repair. (AU)

• Processo FAPESP: 18/18440-0 - Bioprospecção de produtos naturais em terapia fotodinâmica contra micro-organismos de interesse médico-odontológico
• Beneficiário: Analú Barros de Oliveira
• Modalidade de apoio: Bolsas no Brasil - Mestrado
• Processo FAPESP: 20/07110-0 - Potencial da terapia fotodinâmica na modulação da resposta inflamatória e nos fatores de virulência microbianos: avaliação em modelo de co-culturas tridimensionais de fibroblastos gengivais, Candida albicans e Staphylococcus aureus
• Beneficiário: Analú Barros de Oliveira
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 21/01191-0 - Indução de tolerância e caracterização do biofime de Candida albicans submetido à terapia fotodinâmica antimicrobiana
• Beneficiário: Túlio Morandin Ferrisse
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 19/08375-0 - Potencialização do efeito anticárie e antibiofilme de substâncias convencionais: avaliação em modelo de biofilme polimicrobiano
• Beneficiário: Fernanda Lourenção Brighenti
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 18/23015-7 - Terapia fotodinâmica antimicrobiana via irradiação em modo contínuo e chaveado contra Enterococcus faecalis e Cutibacterium acnes
• Beneficiário: Carla Raquel Fontana
• Modalidade de apoio: Auxílio à Pesquisa - Regular