A systematic review and meta-analysis of the effect of photodynamic therapy for the treatment of oral mucositis

Author(s)

de Oliveira, Analu Barros ^[1] ; Ferrisse, Tulio Morandin ^[2] ; Basso, Fernanda Goncalves ^[3] ; Fontana, Carla Raquel ^[4] ; Aparecida Giro, Elisa Maria ^[1] ; Brighenti, Fernanda Lourencao ^[1]

Affiliation

^[1] Sao Paulo State Univ, Sch Dent, Dept Morphol Genet Orthodont & Pediat Dent, UNESP, Araraquara, SP - Brazil

^[2] Sao Paulo State Univ, Sch Dent, UNESP, Dept Dent Mat & Prosthesis, Araraquara, SP - Brazil

^[3] Univ Ribeirao Preto, UNAERP, Dept Dent, Ribeirao Preto, SP - Brazil

^[4] Sao Paulo State Univ, Sch Pharmaceut Sci, Dept Clin Anal, UNESP, Araraquara, SP - Brazil

• Document type: Review article
• Source: Photodiagnosis and Photodynamic Therapy; v. 34, JUN 2021.
• Web of Science Citations: 0

Abstract

Background: Oral mucositis is a significant reaction to antineoplastic treatment characterized with pain, nutritional compromise, impact on the quality of life, interruption in cancer therapy and risk for infection. There is no effective standard protocol for the treatment of oral mucositis. This study aims to synthesize the scientific evidence available about the effects of photodynamic therapy on treatment of oral mucositis. Methods: PubMed, Scopus, Web of Science, Science Direct, Scielo, Embase and Cochrane libraries were searched. Two independent and calibrated researchers (kappa = 0.92) performed all systematic steps according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). To access the risk of bias, RoB 2 and Delphi list criteria for clinical trials were used. Meta-analysis was conducted using the R software with ``META{''} package. Results: Clinical and randomized clinical trials were included with a total of five articles. Meta-analysis, level of evidence, and risk of bias assessment were performed showing that photodynamic therapy was effective in reducing healing time in association with low-power laser therapy when compared to low-power laser therapy alone (p = 0.0005). Conclusion: Photodynamic therapy presents promising results for the treatment of oral mucositis. It may be an effective therapeutic option, contributing to the healing of injured tissues especially in the time needed for repair. (AU)

• FAPESP's process: 18/18440-0 - Bioprospection of natural products in photodynamic therapy against microorganisms of medial and dental importance
• Grantee: Analú Barros de Oliveira
• Support Opportunities: Scholarships in Brazil - Master
• FAPESP's process: 20/07110-0 - Potential of photodynamic therapy in modulating the inflammatory response and microbial virulence factors: evaluation in a model of three-dimensional co-cultures of gingival fibroblasts, Candida albicans and Staphylococcus aureus
• Grantee: Analú Barros de Oliveira
• Support Opportunities: Scholarships in Brazil - Doctorate
• FAPESP's process: 21/01191-0 - Tolerance induction and Candida albicans's biofilm characterization after antimicrobial photodymamic therapy application
• Grantee: Túlio Morandin Ferrisse
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• FAPESP's process: 19/08375-0 - Maximization of the anti-caries and antibiofilm effect of conventional substances: evaluation in a polymicrobial biofilm model
• Grantee: Fernanda Lourenção Brighenti
• Support Opportunities: Regular Research Grants
• FAPESP's process: 18/23015-7 - Antimicrobial photodynamic therapy by continuous and switched mode irradiation against Enterococcus faecalis and Cutibacterium acnes
• Grantee: Carla Raquel Fontana
• Support Opportunities: Regular Research Grants