The chemical interaction between the neurotransmitter dopamine and the antipsychotic drugs olanzapine and quetiapine

Autor(es)

Bacil, Raphael P. ^[1] ; Marcondes Filho, Estenio A. de O. ^[1] ; Dias, Kevin de A. ^[1] ; Portes, Marcelo C. ^[1] ; de Araujo, William R. ^[2] ; Oliveira-Silva, Diogo ^[3] ; dos Santos, Alcindo A. ^[1] ; Serrano, Silvia H. P. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Inst Quim, Av Prof Lineu Prestes 748, Sao Paulo, SP - Brazil

^[2] Univ Estadual Campinas UNICAMP, Inst Quim, Rua Josue de Castro 126, Campinas, SP - Brazil

^[3] Univ Fed Sao Paulo UNIFESP, Inst Ciencias Ambientais Quim & Farmaceut ICAQF, Dept Quim, Rua Prof Arthur Riedel 275, Diadema, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: JOURNAL OF ELECTROANALYTICAL CHEMISTRY; v. 881, JAN 15 2021.
• Citações Web of Science: 2

Resumo

Mental disorders like schizophrenia affect about 0.7% of the world population. Nowadays, the treatment consists of atypical antipsychotic drugs, mainly olanzapine and quetiapine. In this paper, we observed the chemical interaction between both olanzapine and quetiapine, antipsychotic drugs, with dopamine in phosphate buffer solutions at physiological pH using cyclic and differential voltammetry techniques, UV-Vis and EPR spectra. A solution containing both antipsychotic drugs and dopamine resulted in a shift of dopamine's redox processes, hindering its electrochemical oxidation. The chemical interaction was voltametrically investigated and a mechanism is proposed. In addition, it was observed that the reactions of both drugs with DA are first-order, presenting kinetic rate constants of 1.5 10(-2) s(-1) and 9.0 10(-3) s(-1) for olanzapine and quetiapine, respectively, at pH=7.4. To further evaluate the chemical reaction, aminimalist model between PIPES molecule and catechol was proposed and tested. The model presented a similar signal decrease and kinetic rate constant to those observed for both olanzapine and quetiapine reaction with dopamine, reinforcing the data obtained which strongly suggests that the chemical reaction occurs between piperazine and catechol moieties. (AU)

• Processo FAPESP: 13/07937-8 - Redoxoma
• Beneficiário: Ohara Augusto
• Modalidade de apoio: Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs