Vitamin E-loaded bigels and emulsions: Physicochemical characterization and potential biological application

Autor(es)

Martinez, Renata Miliani ^[1] ; Magalhaes, Wagner Vidal ^[2] ; Sufi, Bianca da Silva ^[2] ; Padovani, Giovana ^[2] ; Sbrugnera Nazato, Lucas Idacir ^[2] ; Robles Velasco, Maria Valeria ^[1] ; da Silva Lannes, Suzana Caetano ^[3] ; Baby, Andre Rolim ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Sch Pharmaceut Sci, Dept Pharm, 580 Prof Lineu Prestes Av, Bl 15, BR-05508 Sao Paulo, SP - Brazil

^[2] Chemyunion Ltd, Res & Dev Lab, 1501 Av Independencia, BR-18087 Sorocaba, SP - Brazil

^[3] Univ Sao Paulo, Sch Pharmaceut Sci, Dept Pharmaceut Biochem Technol, 580 Prof Lineu Prestes Av, Bl 13, BR-05508900 Sao Paulo, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: COLLOIDS AND SURFACES B-BIOINTERFACES; v. 201, MAY 2021.
• Citações Web of Science: 0

Resumo

Bigels have been studied as topical formulations for its benefits over sensory and drug delivery parameters. However, there is still few evidences about the properties of the combination of organogelators, oily phases and bioactive molecules into rheological and stability behavior. We investigated the use of classical organogelators (candelilla wax and 12-hydroxystearic acid) and oily phases (sunflower and mineral oil) in 5/95 organogel/ polymeric hydrogel ratio to compare vitamin E bigels with its corresponding emulsions. The rheological measurements, microstructure, physical and oxidative stability properties and biological behavior were evaluated. The obtained oil-in-water bigels and emulsions showed crystallization pattern at the interface with high thermal and centrifuge-stress stability. Viscoelastic weak gels were obtained with higher thixotropy and consistency of 12-hydroxystearic bigels. The diameter of the inner phase was increased by vitamin E, despite its little influence over physical and oxidative stability of bigels and emulsions. Those findings indicated that sensory attributes may be regulated by the organogel composition. (AU)

• Processo FAPESP: 16/24360-4 - Eficácia antilipoperoxidativa e anti-inflamatória de protetores solares multifuncionais contendo ácido ferúlico
• Beneficiário: André Rolim Baby
• Modalidade de apoio: Auxílio à Pesquisa - Regular