| Texto completo | |
| Autor(es): |
Gonzales, Julia Cunha
[1]
;
Seribelli, Amanda Aparecida
[1]
;
Gomes, Carolina Nogueira
[1]
;
dos Prazeres Rodrigues, Dalia
[2]
;
Campioni, Fabio
[1]
;
Passaglia, Jaqueline
[1]
;
da Silva, Paulo
[3]
;
Falcao, Juliana Pfrimer
[1]
Número total de Autores: 8
|
| Afiliação do(s) autor(es): | [1] Univ Sao Paulo, Dept Anal Clin Toxicol & Bromatol, Fac Ciencias Farmaceut Ribeirao Preto, Ave Cafe S-No, Campus Univ USP, BR-14040903 Ribeirao Preto, SP - Brazil
[2] Fundacao Oswaldo Cruz, Rio De Janeiro - Brazil
[3] Inst Adolfo Lutz Ribeirao Preto, Sao Paulo - Brazil
Número total de Afiliações: 3
|
| Tipo de documento: | Artigo Científico |
| Fonte: | Brazilian Journal of Microbiology; v. 51, n. 4, p. 1563-1571, DEC 2020. |
| Citações Web of Science: | 0 |
| Resumo | |
Shigella flexnerihas been a major public health problem in developing countries. This work analyzed the frequency of 16 virulence genes, the genotypic diversity, and the antimicrobial resistance profiles of 130S. flexneristrains isolated in Brazil. TheipaHgene was found in all the 130 strains. The frequencies of the other genes were variableial(88.5%),sigA(82.3%),iuc(74.6%),virA(73%),pic(72.3%),virF (57.7%),sat(48.5%),ipaBCD(37%),sen(36%),set1A(35.4%),sepA(30%),set 1B(30%),virB(14%),icsA(10%), andipgD(5.4%). A total of 57 (43.8%) strains were multidrug-resistant. ERIC-PCR grouped 96 of the strains into a single cluster with >= 70.4% of similarity, 75 of these strains presented a similarity >= 80.9%. PFGE grouped 120 of the strains into a single cluster with 57.4% of similarity and 82 of these strains presented a similarity >= 70.6%. In conclusion, the high frequency of some virulence genes reinforces the pathogenic potential of the strains studied. The high rates of MDR strains are alarming once it may lead to failure when antimicrobial treatment is necessary. Genotype techniques reveled a major cluster with high genetic similarity includingS. flexneristrains from the different Brazilian states and distinct years of isolation, showing that they probably emerged from a common ancestor. (AU) | |
| Processo FAPESP: | 14/13029-0 - Caracterização molecular de linhagens de Campylobacter jejuni e Campylobacter coli de origens diversas |
| Beneficiário: | Juliana Pfrimer Falcão |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |