Nandrolone decanoate and resistance exercise affect body composition and energy metabolism

Autor(es)

Pozzi, Renan ^{[1, 2]} ; Fernandes, Leandro ^[2] ; da Silva, Vanessa Cavalcante ^[2] ; D'Almeida, Vania ^[2]

Afiliação do(s) autor(es)

^[1] Univ Fed Sao Paulo, UNIFESP, Dept Biosci, Sao Paulo, SP - Brazil

^[2] Univ Fed Sao Paulo, UNIFESP, Dept Psychobiol, Sao Paulo, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Steroids; v. 174, OCT 2021.
• Citações Web of Science: 0

Resumo

Our aim was to evaluate the independent and associated effects of nandrolone decanoate (DECA) and resistance exercise (REx) on central and peripheral hormones and neuropeptides related to energy balance in male rats. The experimental protocol was performed for eight weeks and comprised four groups: control (C) - exposed to vehicle 3x/wk; trained (T) - REx 5x/wk and vehicle 3x/wk; decanoate (D) - exposed to DECA (5 mg/kg) 3x/wk, and REx with DECA (TD) - submitted to REx 5x/wk and DECA (5 mg/kg) 3x/wk. Cross-sectional area analysis of the gastrocnemius muscle was higher in the T and TD groups compared to the C group. Biometrical analyses showed a decrease in body weight only in the TD compared to the C group, however, a reduction in total fat mass was observed in both the T and TD when compared to the C group. In respect of hypothalamic mRNA expression, there was an increase in prepro-orexin in the T compared to the C group. In mesenteric fat there was a decrease in leptin expression in the T and TD compared to the C group. Plasma evaluations showed reduced leptin concentrations in D, T and TD compared to C, and an increase in orexin-A in the D group compared to the C and T groups. Our data showed that REx was related to central and peripheral changes in energy metabolism, while DECA changed only peripheral components. REx associated with DECA promoted peripheral changes in energy metabolism and decreased body and fat weights. (AU)

• Processo FAPESP: 13/05549-0 - Alterações centrais e periféricas relacionados ao balanço energético de ratos submetidos ao exercício resistido e expostos ao decanoato de nandrolona
• Beneficiário: Renan Pozzi
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 13/17587-4 - Alterações centrais e periféricas relacionadas ao balanço energético de ratos submetidos ao exercício resistido e expostos ao decanoato de nandrolona
• Beneficiário: Vânia D'Almeida
• Modalidade de apoio: Auxílio à Pesquisa - Regular