| Texto completo | |
| Autor(es): |
Gardim, Camila B.
[1]
;
Veiga, Ana Catarine
[1]
;
Aguilar, Bruno A.
[1]
;
Philbois, Stella V.
[1]
;
Souza, Hugo C. D.
[1]
Número total de Autores: 5
|
| Afiliação do(s) autor(es): | [1] Univ Sao Paulo, Ribeirao Preto Med Sch, Ribeirao Preto, SP - Brazil
Número total de Afiliações: 1
|
| Tipo de documento: | Artigo Científico |
| Fonte: | SCIENTIFIC REPORTS; v. 11, n. 1 AUG 25 2021. |
| Citações Web of Science: | 0 |
| Resumo | |
We investigated hemodynamic, cardiac morphofunctional, and cardiovascular autonomic adaptations in spontaneously hypertensive rats (SHRs) after aerobic physical training associated with chronic cholinergic stimulation. Fifty-four SHRs were divided into two groups: trained and untrained. Each group was further subdivided into three smaller groups: vehicle, treated with pyridostigmine bromide at 5 mg/kg/day, and treated with pyridostigmine bromide at 15 mg/kg/day. The following protocols were assessed: echocardiography, autonomic double pharmacological blockade, heart rate variability (HRV), blood pressure variability (BPV), and baroreflex sensitivity (BRS). Physical training and pyridostigmine bromide reduced BP and HR and increased vagal participation in cardiac autonomic tonic balance. The associated responses were then potentialized. Treatment with pyridostigmine bromide increased HRV oscillation of both low frequency (LF: 0.2-0.75 Hz) and high frequency (HF: 0.75-3 Hz). However, the association with physical training attenuated HF oscillations. Additionally, treatment with pyridostigmine bromide also increased LF oscillations of BPV. Both treatment groups promoted morphofunctional adaptations, and associated increased ejection volume, ejection fraction, cardiac output, and cardiac index. In conclusion, the association of pyridostigmine bromide and physical training promoted greater benefits in hemodynamic parameters and increased vagal influence on cardiac autonomic tonic balance. Nonetheless, treatment with pyridostigmine bromide alone seems to negatively affect BPV and the association of treatment negatively influences HRV. (AU) | |
| Processo FAPESP: | 14/00940-6 - Estudo do efeito da estimulação colinérgica crônica com brometo de piridostigmina sobre as adaptações autonômicas cardiovasculares e morfofuncionais cardíacas induzidas pelo treinamento físico aeróbio em Ratos Espontaneamente Hipertensos (SHR) |
| Beneficiário: | Camila Balsamo Gardim |
| Modalidade de apoio: | Bolsas no Brasil - Mestrado |