Could parental high-fat intake program the reproductive health of male offspring? A review

Autor(es)

Sertorio, Marcela Nascimento ^{[1, 2]} ; Estadella, Debora ^[1] ; Ribeiro, Daniel Araki ^[1] ; Pisani, Luciana Pellegrini ^[1]

Afiliação do(s) autor(es)

^[1] Univ Fed Sao Paulo, Dept Biociencias, Santos, SP - Brazil

^[2] Univ Fed Sao Paulo, Programa Posgrad Nutr, Sao Paulo, SP - Brazil

• Tipo de documento: Artigo de Revisão
• Fonte: CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION; AUG 2021.
• Citações Web of Science: 0

Resumo

High-fat diet (HFD) intake can cause overweight and obesity and has become a global public health concern in recent years. Nutritional adversity at vulnerable windows of development can affect developing cells and their functions, including germ cells. Evidence shows that parental HFD intake prior to conception and/or during gestation and lactation could program the reproductive health of male offspring, ultimately resulting in impairment of the first as well as subsequent generations. In male offspring, adipose tissue and hypothalamic-pituitary-gonadal axis imbalance can impair the production of gonadotropins, leading to dysfunction of testosterone production and pubertal onset. The gonads can be directly impaired through oxidative stress, causing poor testosterone production and spermatogenesis; low sperm count, viability, and motility; and abnormal sperm morphology, which results in low sperm quality. Parental HFD intake could also be a risk factor for prostate hyperplasia and cancer in advanced age. It can impact the reproductive pattern of male offspring resulting in impairments in the subsequent generations. The investigation of semen quality must be extended to epidemiological and clinical studies of the male offspring of overweight and/or obese parents in order to improve the quality of human semen. This review addresses the effects of parental HFD intake on the reproductive parameters of male offspring and discusses the possible underlying mechanisms. (AU)

• Processo FAPESP: 19/09724-8 - Influência da ingestão materna e paterna de dieta hiperlipídica/hiperglicídica no eixo cólon-hipotálamo da prole no início da vida adulta
• Beneficiário: Luciana Pellegrini Pisani
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 18/17412-3 - Efeitos da ingestão materna e paterna de dieta hiperlipídica e hiperglicídica na programação reprodutiva masculina da prole no início da vida adulta
• Beneficiário: Marcela Nascimento Sertorio
• Modalidade de apoio: Bolsas no Brasil - Doutorado