Actions and Roles of FSH in Germinative Cells

Autor(es)

Recchia, Kaiana ^[1] ; Jorge, Amanda Soares ^[2] ; de Figueiredo Pessoa, Lais Vicari ^[2] ; Botigelli, Ramon Cesar ^{[2, 3]} ; Zugaib, Vanessa Cristiane ^[2] ; de Souza, Aline Fernanda ^[4] ; Martins, Daniele dos Santos ^[2] ; Ambrosio, Carlos Eduardo ^[2] ; Bressan, Fabiana Fernandes ^{[2, 1]} ; Godoy Pieri, Naira Caroline ^[2]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Fac Vet Med & Anim Sci, Dept Surg, BR-01001010 Sao Paulo - Brazil

^[2] Univ Sao Paulo, Sch Anim Sci & Food Engn, Dept Vet Med, BR-13635900 Pirassununga - Brazil

^[3] Sao Paulo State Univ UNESP, Inst Biosci, Dept Pharmacol, BR-18618970 Botucatu, SP - Brazil

^[4] Univ Guelph, Ontary Vet Coll, Dept Biomed Sci, Guelph, ON N1G 2W1 - Canada

• Tipo de documento: Artigo de Revisão
• Fonte: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES; v. 22, n. 18 SEP 2021.
• Citações Web of Science: 0

Resumo

Follicle stimulating hormone (FSH) is produced by the pituitary gland in a coordinated hypothalamic-pituitary-gonadal (HPG) axis event, plays important roles in reproduction and germ cell development during different phases of reproductive development (fetal, neonatal, puberty, and adult life), and is consequently essential for fertility. FSH is a heterodimeric glycoprotein hormone of two dissociable subunits, alpha and beta. The FSH beta-subunit (FSH beta) function starts upon coupling to its specific receptor: follicle-stimulating hormone receptor (FSHR). FSHRs are localized mainly on the surface of target cells on the testis and ovary (granulosa and Sertoli cells) and have recently been found in testicular stem cells and extra-gonadal tissue. Several reproduction disorders are associated with absent or low FSH secretion, with mutation of the FSH beta-subunit or the FSH receptor, and/or its signaling pathways. However, the influence of FSH on germ cells is still poorly understood; some studies have suggested that this hormone also plays a determinant role in the self-renewal of germinative cells and acts to increase undifferentiated spermatogonia proliferation. In addition, in vitro, together with other factors, it assists the process of differentiation of primordial germ cells (PGCLCs) into gametes (oocyte-like and SSCLCs). In this review, we describe relevant research on the influence of FSH on spermatogenesis and folliculogenesis, mainly in the germ cell of humans and other species. The possible roles of FSH in germ cell generation in vitro are also presented. (AU)

• Processo FAPESP: 12/05609-0 - Espermatogênese xenogênica pós-transplante de células tronco caninas no testículo de camundongos
• Beneficiário: Naira Caroline Godoy Pieri
• Modalidade de apoio: Bolsas no Brasil - Doutorado