Identification of azaphilone derivatives of Monascus colorants from Talaromyces amestolkiae and their halochromic properties

Autor(es)

de Oliveira, Fernanda ^[1] ; Rocha, Ines L. D. ^[2] ; Gouveia Alves Pinto, Diana Claudia ^{[3, 4]} ; Ventura, Sonia P. M. ^[2] ; dos Santos, Andre Gonzaga ^[5] ; Crevelin, Eduardo Jose ^[6] ; Santos Ebinuma, Valeria de Carvalho ^[1]

Afiliação do(s) autor(es)

^[1] Sao Paulo State Univ UNESP, Sch Pharmaceut Sci, Dept Engn Bioproc & Biotechnol, Campus Araraquara, Rodovia Araraquara Jau Km 01, BR-14800903 Araraquara, SP - Brazil

^[2] Univ Aveiro, CICECO Aveiro Inst Mat, Chem Dept, Campus Univ Santiago, P-3810193 Aveiro - Portugal

^[3] Univ Aveiro, P-3810193 Aveiro - Portugal

^[4] LAQV REQUIMTE, Dept Chem, P-3810193 Aveiro - Portugal

^[5] Sao Paulo State Univ UNESP, Sch Pharmaceut Sci, Dept Drugs & Med, Araraquara, SP - Brazil

^[6] Univ Sao Paulo, Fac Philosophy Sci & Letters Ribeirao Preto FFCLR, Dept Chem, Lab Mass Spectrometry Appl Nat Prod Chem, Ribeirao Preto, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Food Chemistry; v. 372, MAR 15 2022.
• Citações Web of Science: 0

Resumo

Currently, the ability to produce several kinds of water-soluble red natural colorants makes the genus Talaromyces particularly important to the dye industry, which can be an alternative to the use of harmful synthetic colorants. In this study, colored compounds produced by Talaromyces amestolkiae were extracted, characterized chemically and the color stability of the fermented broth without any extraction procedure was further evaluated over pH variation. Five azaphilones compounds were detected by Ultrahigh Performance Liquid Chromatography-Mass Spectrometry system, all being complexes of the fatty acid amino-hexanedioic acid and azaphilone Monascus colorants. The color of the fermented broth was stable at a wide range of pH (3-9). Furthermore, T. amestolkiae colorants precipitated through hydrolysis of key chemical groups at extremely acidic (pH 1) and lose red color in extremely basic (pH 13) medium, showing negative halochromism. Nevertheless, these findings enhance the industrial relevance of azaphilone colorants produced by biotechnological process. (AU)

• Processo FAPESP: 14/01580-3 - Processo biotecnológico visando o desenvolvimento de novos colorantes naturais microbianos para aplicação industrial
• Beneficiário: Valéria de Carvalho Santos Ebinuma
• Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores
• Processo FAPESP: 18/06908-8 - Desenvolvimento de nanomateriais sustentáveis para a purificação de fármacos antileucêmicos
• Beneficiário: Valéria de Carvalho Santos Ebinuma
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 19/15493-9 - Desenvolvimento de hidrogéis eletrocondutivos baseados em líquidos iônicos
• Beneficiário: Valéria de Carvalho Santos Ebinuma
• Modalidade de apoio: Auxílio à Pesquisa - Regular