Influence of the treatment with the antineoplastic agents 5-fluorouracil and cisplatin on the severity of experimental periodontitis in rats

Autor(es)

Novaes, Vivian Cristina Noronha ^[1] ; Ervolino, Edilson ^[2] ; Fernandes, Giovani Lopes ^[1] ; Cunha, Clara Possarle ^[1] ; Theodoro, Leticia Helena ^[1] ; Garcia, Valdir Gouveia ^[1] ; de Almeida, Juliano Milanezi ^[1]

Afiliação do(s) autor(es)

^[1] Sao Paulo State Univ UNESP, Dept Diag & Surg, Div Periodont, Sch Dent Aracatuba, St Jose Bonifacio 1193 Vila Mendonca, BR-16015050 Aracatuba, SP - Brazil

^[2] Sao Paulo State Univ UNESP, Dept Basic Sci, Histol Div, Sch Dent Aracatuba, Aracatuba, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: SUPPORTIVE CARE IN CANCER; v. 30, n. 3 OCT 2021.
• Citações Web of Science: 0

Resumo

Purpose The determination on how antineoplastic agents interfere on the progression of periodontitis is critical for improvement and even development of novel therapeutic approaches for periodontal management. This study evaluated the influence of chemotherapy with 5-fluorouracil (5-FU) or cisplatin (CIS) on healthy periodontal tissues and on the progression of experimental periodontitis (EP). Methods One hundred forty-four male rats were divided into six groups (n = 24). Each group was treated with physiological saline solution (PSS) 0.9%, 5-FU, or CIS. Experimental periodontitis (EP) was induced by ligature placement. Animals were euthanized at 7, 15, and 30 days after treatment. Data were statistically analyzed (p <= 0.05). Results The groups with EP and treated with 5-FU or CIS showed lower percentage of bone volume in the furcation region and higher percentage of alveolar bone loss, higher number of TRAP-positive cells, and lower number of PCNA-positive cells when compared group with EP and treated with PSS (p <= 0.05). Groups with EP and treated with 5-FU or CIS showed high immunolabelling pattern of RANKL, TNF-alpha, and IL-1 beta, moderate of BAX, and low of HIF-1 alpha. Histological analysis showed severe tissue breakdown in the groups with EP and treated with 5-FU or CIS. Conclusions Chemotherapy with antineoplastic agents 5-FU and CIS increased the intensity and duration of the inflammation and compromised tissue repair by reduction in cellular and vascular turnover. The more severe periodontal breakdown was caused by 5-FU. (AU)

• Processo FAPESP: 14/11427-8 - Influência de drogas quimioterápicas na evolução da periodontite experimental em ratos
• Beneficiário: Juliano Milanezi de Almeida
• Modalidade de apoio: Auxílio à Pesquisa - Regular