Effects of benzo(a)pyrene at environmentally relevant doses on embryo-fetal development in rats

Autor(es)

Moreira, Suyane Silva ^[1] ; de Lima Inocencio, Leonardo Cesar ^[1] ; Jorge, Barbara Campos ^[1] ; Casali Reis, Ana Carolina ^[1] ; Hisano, Hamilton ^[2] ; Arena, Arielle Cristina ^{[1, 3]}

Afiliação do(s) autor(es)

^[1] Univ Estadual Paulista Botucatu UNESP, Inst Biosci Botucatu, Dept Struct & Funct Biol, Sao Paulo - Brazil

^[2] Embrapa Environm, Jaguariuna, SP - Brazil

^[3] Univ Estadual Paulista Botucatu UNESP, Ctr Toxicol Assistance CEATOX, Inst Biosci Botucatu, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: ENVIRONMENTAL TOXICOLOGY; v. 36, n. 5, p. 831-839, MAY 2021.
• Citações Web of Science: 1

Resumo

Studies have demonstrated that Benzo(a)Pyrene (BaP), a polycyclic aromatic hydrocarbon ubiquituous in the environment, can cause teratogenic effects. Since the majority of studies used in vitro models or high doses of BaP, this study evaluated the teratogenicity, reproductive and developmental performance of low doses of BaP through maternal and fetus examination after daily oral administration of BaP (0; 0.1; 1.0 or 10 mu g/kg) to pregnant Wistar rats from Gestational day (GD) 6 to GD 15 (the organogenesis period). Pregnant rats did not exhibit clinical signs of toxicity during the exposure period. However, dams exposed to the lowest dose of BaP showed a reduction in the erythrocytes number and in the creatinine levels. The groups exposed to 0.1 and 1.0 mu g/kg presented a decrease in placental efficiency, as well as an increase in placental weight. After fetal examination, the treated group with the lowest dose showed a reduced relative anogenital distance, while the curve of normal distribution of weight was changed in the highest dose group. In addition, anomalies evidenced by changes in the renal size and degree of fetal ossification were observed in treated-fetus. In conclusion, treatment with BaP during organogenesis at this dose level is detrimental to the normal development of fetuses. (AU)

• Processo FAPESP: 18/07967-8 - Exposição de ratos machos pré-púberes ao anti-inflamatório ibuprofeno: aspectos reprodutivos na geração F1
• Beneficiário: Dayana Agnes Santos Ferreira
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica
• Processo FAPESP: 18/07394-8 - Investigação de parâmetros reprodutivos de ratos machos expostos ao anti-inflamatório ibuprofeno na pré-puberdade
• Beneficiário: Julia Stein
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica