Dinitrosyl Iron Complexes (DNICs). From Spontaneous Assembly to Biological Roles

Autor(es)

Truzzi, Daniela R. ^[1] ; Medeiros, Nathalia M. ^[1] ; Augusto, Ohara ^[1] ; Ford, Peter C. ^[2]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Inst Quim Sao Paulo, Dept Bioquim, BR-05513970 Sao Paulo - Brazil

^[2] Univ Calif Santa Barbara, Dept Chem & Biochem, Santa Barbara, CA 93106 - USA

• Tipo de documento: Artigo de Revisão
• Fonte: Inorganic Chemistry; v. 60, n. 21, p. 15835-15845, NOV 1 2021.
• Citações Web of Science: 0

Resumo

Dinitrosyl iron complexes (DNICs) are spontaneously and rapidly generated in cells. Their assembly requires nitric oxide (NO), biothiols, and nonheme iron, either labile iron or iron-sulfur clusters. Despite ubiquitous detection by electron paramagnetic resonance in NO-producing cells, the DNIC's chemical biology remains only partially understood. In this Forum Article, we address the reaction mechanisms for endogenous DNIC formation, with a focus on a labile iron pool as the iron source. The capability of DNICs to promote S-nitrosation is discussed in terms of S-nitrosothiol generation associated with the formation and chemical reactivity of DNICs. We also highlight how elucidation of the chemical reactivity and the dynamics of DNICs combined with the development of detection/quantification methods can provide further information regarding their participation in physiological and pathological processes. (AU)

• Processo FAPESP: 19/17483-0 - Dinitrosilos complexos de ferro (DNICs): formação, reatividade e implicações para a fisiopatologia do óxido nítrico
• Beneficiário: Daniela Ramos Truzzi
• Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores
• Processo FAPESP: 13/07937-8 - Redoxoma
• Beneficiário: Ohara Augusto
• Modalidade de apoio: Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs