| Texto completo | |
| Autor(es): |
Santos-Lobato, Bruno L.
[1, 2]
;
Gardinassi, Luiz Gustavo
[3]
;
Bortolanza, Mariza
[4]
;
Peti, Ana Paula Ferranti
[5]
;
Pimentel, Angela V.
[1]
;
Faccioli, Lucia Helena
[5]
;
Del-Bel, Elaine A.
[4]
;
Tumas, Vitor
[1]
Número total de Autores: 8
|
| Afiliação do(s) autor(es): | [1] Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Neurosci & Behav Sci, Av Bandeirantes 3900, BR-14049900 Ribeirao Preto, SP - Brazil
[2] Fed Univ Para, Lab Neuropatol Expt, Belem, PA - Brazil
[3] Univ Fed Goias, Inst Trop Pathol & Publ Hlth, Dept Biosci & Technol, Goiania, Go - Brazil
[4] Univ Sao Paulo, Fac Odontol Ribeirao Preto, Dept Basic & Oral Biol, Av Cafe, S-N, BR-14049900 Ribeirao Preto, SP - Brazil
[5] Univ Sao Paulo, Sch Pharmaceut Sci Ribeirao Preto, Dept Clin Anal Toxicol & Food Sci, Ribeirao Preto, SP - Brazil
Número total de Afiliações: 5
|
| Tipo de documento: | Artigo Científico |
| Fonte: | Molecular Neurobiology; v. 59, n. 2 DEC 2021. |
| Citações Web of Science: | 1 |
| Resumo | |
The existence of few biomarkers and the lack of a better understanding of the pathophysiology of levodopa-induced dyskinesia (LID) in Parkinson's disease (PD) require new approaches, as the metabolomic analysis, for discoveries. We aimed to identify a metabolic profile associated with LID in patients with PD in an original cohort and to confirm the results in an external cohort (BioFIND). In the original cohort, plasma and CSF were collected from 20 healthy controls, 23 patients with PD without LID, and 24 patients with PD with LID. LC-MS/MS and metabolomics data analysis were used to perform untargeted metabolomics. Untargeted metabolomics data from the BioFIND cohort were analyzed. We identified a metabolic profile associated with LID in PD, composed of multiple metabolic pathways. In particular, the dysregulation of the glycosphingolipid metabolic pathway was more related to LID and was strongly associated with the severity of dyskinetic movements. Furthermore, bile acid biosynthesis metabolites simultaneously found in plasma and CSF have distinguished patients with LID from other participants. Data from the BioFIND cohort confirmed dysregulation in plasma metabolites from the bile acid biosynthesis pathway. There is a distinct metabolic profile associated with LID in PD, both in plasma and CSF, which may be associated with the dysregulation of lipid metabolism and neuroinflammation. (AU) | |
| Processo FAPESP: | 14/07125-6 - Novos aspectos funcionais dos eicosanóides |
| Beneficiário: | Lúcia Helena Faccioli |
| Modalidade de apoio: | Auxílio à Pesquisa - Temático |
| Processo FAPESP: | 12/17626-7 - Mecanismos celulares e moleculares envolvidos no papel de neurotransmissores atípicos em transtornos neuropsiquiátricos |
| Beneficiário: | Francisco Silveira Guimaraes |
| Modalidade de apoio: | Auxílio à Pesquisa - Temático |