Prevalence of infection by human T Cell lymphotropic viruses (HTLV-1/2) in adult population in Vitoria-ES

Autor(es)

Orletti, Maria P. S. ^[1] ; Assone, Tatiane ^{[2, 3]} ; Sarnaglia, Glenia Daros ^[1] ; Martins, Marina Lobato ^[4] ; Rosadas, Carolina ^[5] ; Casseb, Jorge ^[3] ; Taylor, Graham ^[5] ; Ferreira-Filho, Joaquim B. ^[1] ; Pereira, Fausto E. L. ^[1] ; Miranda, Angelica Espinosa ^{[1, 2]}

Afiliação do(s) autor(es)

^[1] Univ Fed Espirito Santo, Programa Posgrad Doencas Infecciosas, Vitoria, ES - Brazil

^[2] Ministerio Saude, Secretaria Vigilancia Saude, Brasilia, DF - Brazil

^[3] Univ Sao Paulo, Fac Med, Inst Med Trop Sao Paulo, Sao Paulo, SP - Brazil

^[4] Interdisciplinary HTLV Res Grp, Belo Horizonte, MG - Brazil

^[5] Imperial Coll London, Virol Sect, Dept Infect Dis, London - England

• Tipo de documento: Artigo Científico
• Fonte: Brazilian Journal of Infectious Diseases; v. 25, n. 5 SEP-OCT 2021.
• Citações Web of Science: 0

Resumo

Introduction: Brazil has a high number of HTLV-1/2 infections which are unequally distributed in the country. Most prevalence studies have focused on specific populations, such as blood donors and pregnant women. Some areas, for example the state of Bahia, have robust information about HTLV-1/2 infection, however there is no information available about this infection in the general population of Vitoria, Espirito Santo, Brazil. Objective: To determine the prevalence of HTLV-1/2 infection in adults from the municipality of Vitoria, ES. Methods: A cross sectional study was performed from September 2010 to December 2011, in individuals of both sexes, aged 18 or older living in Vit = oria-ES. Venous blood samples were collected and tested for anti-HTLV-1/2 antibodies by chemiluminescent immunoassay (CMIA). Individuals with CMIA reactive results were submitted to a new blood collection for retesting by CMIA, followed by PCR to confirm infection and discriminate the viral type. Results: From 1502 tested samples, eight were reactive in CMIA and all were confirmed by PCR. Therefore, the prevalence of HTLV-1/2 was 0.53% (8/1502, 95% CI: 0.2-1.0%). The infection rate was 0.7% in men (5/711, 95% CI: 0.17-1.51%), and 0.38% in women (3/791, 95% CI: 0 - 0.81%). Conclusions: The prevalence of HTLV-1/2 infection was 0.53% (8/1502; 95% CI: 0.2 - 0.9%). Confirmatory test using real-time PCR (qPCR) identified seven individuals positive for HTLV-1 and one for HTLV-2. Considering the risk of infected individuals to develop high morbidity and mortality diseases, it would be important to implement public health policies aimed at stopping transmission of these viruses in this municipality. (C) 2021 Sociedade Brasileira de Infectologia. Published by Elsevier Espana, S.L.U. (AU)

• Processo FAPESP: 16/03025-2 - Identificação de polimorfismos relacionados à mielopatia associada ao HTLV-1/paraparesia espástica tropical (HAM/TSP)
• Beneficiário: Tatiane Assone Casseb
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado