Rocio Virus: An Updated View on an Elusive Flavivirus

Autor(es)

Saivish, Marielena Vogel ^[1] ; da Costa, Vivaldo Gomes ^[2] ; Menezes, Gabriela de Lima ^[3] ; da Silva, Roosevelt Alves ^[3] ; Dutra da Silva, Gislaine Celestino ^[1] ; Moreli, Marcos Lazaro ^[3] ; Sacchetto, Livia ^[1] ; Pacca, Carolina Colombelli ^{[2, 4]} ; Vasilakis, Nikos ^{[5, 6, 7, 8, 9]} ; Nogueira, Mauricio Lacerda ^{[5, 1]}

Afiliação do(s) autor(es)

^[1] Fac Med Sao Jose do Rio Preto, Lab Pesquisas Virol, Dept Doencas Dermatol Infecciosas & Parasitarias, BR-15090000 Sao Jose Do Rio Preto, SP - Brazil

^[2] Univ Estadual Paulista, UNESP, Inst Biociencias Letras & Ciencias Exatas, BR-15054000 Sao Jose Do Rio Preto, SP - Brazil

^[3] Univ Fed Jatai, Nucleo Colaborat Biosistemas, BR-75801615 Jatai, Go - Brazil

^[4] Fac Faceres, Inst Super Educ Ceres, BR-15090000 Sao Jose Do Rio Preto, SP - Brazil

^[5] Univ Texas Med Branch, Dept Pathol, 301 Univ Blvd, Galveston, TX 77555 - USA

^[6] Univ Texas Med Branch, Ctr Biodef & Emerging Infect Dis, 301 Univ Blvd, Galveston, TX 77555 - USA

^[7] Univ Texas Med Branch, Ctr Trop Dis, 301 Univ Blvd, Galveston, TX 77555 - USA

^[8] Univ Texas Med Branch, Inst Human Infect & Immun, 301 Univ Blvd, Galveston, TX 77555 - USA

^[9] Univ Texas Med Branch, Sealy Ctr Vector Borne & Zoonot Dis, 301 Univ Blvd, Galveston, TX 77555 - USA

• Tipo de documento: Artigo de Revisão
• Fonte: Viruses-Basel; v. 13, n. 11 NOV 2021.
• Citações Web of Science: 0

Resumo

Rocio virus (ROCV) is a mosquito-borne flavivirus and human pathogen. The virus is indigenous to Brazil and was first detected in 1975 in the Sao Paulo State, and over a period of two years was responsible for several epidemics of meningoencephalitis in coastal communities leading to over 100 deaths. The vast majority of ROCV infections are believed to be subclinical and clinical manifestations can range from uncomplicated fever to fatal meningoencephalitis. Birds are the natural reservoir and amplification hosts and ROCV is maintained in nature in a mosquito-bird-mosquito transmission cycle, primarily involving Psorophora ferox mosquitoes. While ROCV has remained mostly undetected since 1976, in 2011 it re-emerged in Goias State causing a limited outbreak. Control of ROCV outbreaks depends on sustainable vector control measures and public education. To date there is no specific treatment or licensed vaccine available. Here we provide an overview of the ecology, transmission cycles, epidemiology, pathogenesis, and treatment options, aiming to improve our ability to understand, predict, and ideally avert further ROCV emergence. (AU)

• Processo FAPESP: 20/12875-5 - Desenvolvimento de método de diagnóstico para o vírus Rocio e utilização de compostos novos como inibidores da NS2B-NS3 protease-helicase de flavivirus
• Beneficiário: Marielena Vogel Saivish
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 13/21719-3 - Estudo epidemiológico da dengue (sorotipos 1 a 4) em coorte prospectiva de São José do Rio Preto, São Paulo, Brasil, durante 2014 a 2018
• Beneficiário: Maurício Lacerda Nogueira
• Modalidade de apoio: Auxílio à Pesquisa - Temático