Polycaprolactone usage in additive manufacturing strategies for tissue engineering applications: A review

Autor(es)

Backes, Eduardo Henrique ^[1] ; Harb, Samarah Vargas ^[1] ; Beatrice, Cesar Augusto Goncalves ^[1] ; Shimomura, Kawany Munique Boriolo ^[1] ; Passador, Fabio Roberto ^[2] ; Costa, Lidiane Cristina ^[1] ; Pessan, Luiz Antonio ^[1]

Afiliação do(s) autor(es)

^[1] Univ Fed Sao Carlos, Dept Mat Engn, Grad Program Mat Sci & Engn, Rodovia Washington Luiz, Km 235, BR-13565905 Sao Carlos - Brazil

^[2] Univ Fed Sao Paulo, Inst Sci & Technol, Sao Paulo - Brazil

• Tipo de documento: Artigo de Revisão
• Fonte: JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS; DEC 2021.
• Citações Web of Science: 0

Resumo

Polycaprolactone (PCL) has been extensively applied on tissue engineering because of its low-melting temperature, good processability, biodegradability, biocompatibility, mechanical resistance, and relatively low cost. The advance of additive manufacturing (AM) technologies in the past decade have boosted the fabrication of customized PCL products, with shorter processing time and absence of material waste. In this context, this review focuses on the use of AM techniques to produce PCL scaffolds for various tissue engineering applications, including bone, muscle, cartilage, skin, and cardiovascular tissue regeneration. The search for optimized geometry, porosity, interconnectivity, controlled degradation rate, and tailored mechanical properties are explored as a tool for enhancing PCL biocompatibility and bioactivity. In addition, rheological and thermal behavior is discussed in terms of filament and scaffold production. Finally, a roadmap for future research is outlined, including the combination of PCL struts with cell-laden hydrogels and 4D printing. (AU)

• Processo FAPESP: 18/14151-4 - Desenvolvimento e caracterização de compósitos de PCL/TCP com propriedades bioativas
• Beneficiário: Kawany Munique Boriolo Shimomura
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica
• Processo FAPESP: 17/11366-7 - Desenvolvimento de scaffolds bioinspirados de PLA/biovidros via impressão 3D
• Beneficiário: Eduardo Henrique Backes
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 18/26060-3 - Scaffolds bioativos e bactericidas para regeneração óssea via impressão 3D
• Beneficiário: Samarah Vargas Harb
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 17/09609-9 - Desenvolvimento de scaffolds bioinspirados de PLA/cargas cerâmicas bioativas via impressão 3D
• Beneficiário: Luiz Antonio Pessan
• Modalidade de apoio: Auxílio à Pesquisa - Regular