Early Signs of Inflammation With Mild Oxidative Stress in Mixed Martial Arts Athletes After Simulated Combat

Autor(es)

Gomes-Santos, Jose Alberto Fernandes ^[1] ; Lambertucci, Rafael Herlich ^[2] ; Vardaris, Cristina Vasconcelos ^[1] ; Passos, Maria Elizabeth Pereira ^[1] ; Silva-Junior, Edenilson Pinto ^[1] ; Hatanaka, Elaine ^[1] ; Gorjao, Renata ^[1] ; McAnulty, Steven Roy ^[3] ; Souza-Junior, Tacito Pessoa ^{[4, 3]} ; de Barros, Marcelo Paes ^[1]

Afiliação do(s) autor(es)

^[1] Cruzeiro do Sul Univ, Inst Phys Act & Sports Sci ICAFE, Program Hlth Sci, Sao Paulo, SP - Brazil

^[2] Fed Univ Sao Paulo UNIFESP, Inst Hlth & Soc, Dept Human Movement Sci, Santos, SP - Brazil

^[3] Appalachian State Univ, Dept Hlth & Exercise Sci, Boone, NC 28608 - USA

^[4] Fed Univ Parana UFPR, Dept Phys Educ, Curitiba, Parana - Brazil

• Tipo de documento: Artigo Científico
• Fonte: JOURNAL OF STRENGTH AND CONDITIONING RESEARCH; v. 36, n. 1, p. 180-186, JAN 2022.
• Citações Web of Science: 0

Resumo

Gomes-Santos, JAF, Lambertucci, RH, Vardaris, CV, Passos, MEP, Silva-Junior, EP, Hatanaka, E, Gorjao, R, McAnulty, SR, Souza-Junior, TP, and Barros, MP. Early signs of inflammation with mild oxidative stress in Mixed Martial Arts athletes after simulated combat. J Strength Cond Res 36(1): 180-186, 2022-Combat sports involve a combination of strenuous physical activity, usually at the anaerobic threshold, followed by intermittent low-intensity recovery periods for energy re-establishment. Oxidative stress and inflammation are inevitable exercise-related processes that could drastically affect athletic performance and practitioners' health, unless efficiently controlled during and after physical activities. This study aims to measure oxidative stress and inflammation biomarkers in the plasma of 12 top ranked professional Mixed Martial Arts (MMAs) athletes before and after simulated combats under official rules (pre-post study). Our results show that the athletes exhibited mild oxidative imbalances in plasma, evidenced by significant (p < 0.01) higher contents of both reduced (+7.3%) and oxidized glutathione (+28%), uric acid (+21%), and ``free{''} iron (+21%) after combat, whereas variation tendencies (0.05 < p < 0.01) were observed in the antioxidant capacity in plasma (-40%), and SOD (-27%) or GPX (+20%) antioxidant activities in erythrocytes. However, a clear pro-inflammatory state was detected by increases in circulating cytokines IL-6 (+6,020%), IL-1 beta (+4,357%), and tumor necrosis factor alpha (+63%), and by an abrupt drop of the anti-inflammatory cytokine IL-10 (-98%). A significant correlation was observed between pre-post variations of IL-6 and GSH/GSSG ratio in plasma (p < 0.0001), which reinforces the integration between oxidative stress and inflammation during MMA combats. Considering metabolic and mechanical stresses (imposed by combat techniques, e.g., punches and joint locks), this study indicates pre-existing inflammation, although minor oxidative stress, in MMA professionals after combat. (AU)

• Processo FAPESP: 17/06032-2 - Estratégias bioquímicas, fisiológicas e transcriptômicas para o estudo da relação entre carotenóides, estresse oxidativo e qualidade de frutas cítricas
• Beneficiário: Marcelo Paes de Barros
• Modalidade de apoio: Bolsas no Exterior - Pesquisa