Prognostic Value of Intratumoral Collagen Quantification in Canine Oral Melanomas

Autor(es)

Leite, Natalia Goulart ^[1] ; Moroni Vargas, Thiago Henrique ^[1] ; Ferro, Daniel Giberne ^[2] ; Sobral, Renata Afonso ^[3] ; Francoise Anita Venturini, Michele Alice ^[2] ; Correa, Herbert Lima ^[2] ; Strefezzi, Ricardo De Francisco ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Fac Zootecnia & Engn Alimentos, Dept Med Vet, Lab Oncol Comparada & Translac, Pirassununga, SP - Brazil

^[2] Odontovet Ctr Odontol Vet, Sao Paulo, SP - Brazil

^[3] Onco Cane Vet, Sao Paulo, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: JOURNAL OF VETERINARY DENTISTRY; JAN 2022.
• Citações Web of Science: 0

Resumo

The majority of the melanocytic neoplasms are considered malignant and highly metastatic. However, a subset of the melanocytic tumors has a more favorable prognosis and the identification of precise prognostic markers for this neoplasm may be useful to guide treatment. The collagen architecture and density have been shown to correlate with tumor progression in human breast cancer and canine mast cell tumors. The purpose of the present study was to investigate the prognostic value of the intratumoral collagen index (ICI) as an indicator of postsurgical survival and its relation with other prognostic markers for canine oral melanomas (OMs). Twenty-two cases were tested for intratumoral collagen density using Masson's trichrome stain and morphometry. No differences were found between dogs regarding survival. The ICI was not correlated with proliferative activity or nuclear atypia. The results presented herein indicate that the quantity of intratumoral collagen in canine OMs is not an efficient indicator of postsurgical survival. Complementary studies about the expression and activity of enzymes that are capable of degrading extracellular matrix (ECM) components are necessary. (AU)

• Processo FAPESP: 15/11959-2 - Caracterização imuno-histoquímica da galectina-3 como ferramenta prognóstica em melanomas orais caninos
• Beneficiário: Thiago Henrique Moroni Vargas
• Modalidade de apoio: Bolsas no Brasil - Mestrado
• Processo FAPESP: 16/03862-1 - Caracterização de fibroblastos associados ao câncer e sua influência sobre neoplasias caninas
• Beneficiário: Ricardo de Francisco Strefezzi
• Modalidade de apoio: Auxílio à Pesquisa - Regular