ynthesis, In Vitro Testing, and Biodistribution of Surfactant-Free Radioactive Nanoparticles for Cancer Treatmen

Autor(es):Mostrar menos -

Daruich de Souza, Carla ^[1] ; Bueno Barbezan, Angelica ^[1] ; Arcos Rosero, Wilmmer Alexander ^[1] ; Nascimento dos Santos, Sofia ^[1] ; Vergacas de Sousa Carvalho, Diego ^[1] ; Zeituni, Carlos Alberto ^[1] ; Soares Bernardes, Emerson ^[1] ; Perez Vieira, Daniel ^[1] ; Spencer, Patrick Jack ^[1] ; Simoes Ribeiro, Martha ^[1] ; Chuery Martins Rostelato, Maria Elisa ^[1]

Afiliação do(s) autor(es)

^[1] IPEN CNEN, Nucl & Energy Res Inst, BR-05508000 Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: NANOMATERIALS; v. 12, n. 2 JAN 2022.
• Citações Web of Science: 0

Resumo

New forms of cancer treatment, which are effective, have simple manufacturing processes, and easily transportable, are of the utmost necessity. In this work, a methodology for the synthesis of radioactive Gold-198 nanoparticles without the use of surfactants was described. The nuclear activated Gold-198 foils were transformed into (HAuCl4)-Au-198 by dissolution using aqua regia, following a set of steps in a specially designed leak-tight setup. Gold-198 nanoparticles were synthesized using a citrate reduction stabilized with PEG. In addition, TEM results for the non-radioactive product presented an average size of 11.0 nm. The DLS and results for the radioactive (198)AuNPs presented an average size of 8.7 nm. Moreover, the DLS results for the PEG-(198)AuNPs presented a 32.6 nm average size. Cell line tests showed no cytotoxic effect in any period and the concentrations were evaluated. Furthermore, in vivo testing showed a high biological uptake in the tumor and a cancer growth arrest. (AU)

• Processo FAPESP: 18/18526-2 - Nanofonte Radioativa para Utilização em Braquiterapia
• Beneficiário: Carla Daruich de Souza
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 17/50332-0 - Capacitação científica, tecnológica e em infraestrutura em radiofármacos, radiações e empreendedorismo a serviço da saúde (PDIp)
• Beneficiário: Marcelo Linardi
• Modalidade de apoio: Auxílio à Pesquisa - Programa Modernização de Institutos Estaduais de Pesquisa