| Texto completo | |
| Autor(es): |
Carvalho, Bruna G.
[1]
;
Ceccato, Bruno T.
[1]
;
Michelon, Mariano
[2]
;
Han, Sang W.
[3]
;
de la Torre, Lucimara G.
[1]
Número total de Autores: 5
|
| Afiliação do(s) autor(es): | [1] Univ Campinas UNICAMP, Sch Chem Engn, Dept Mat & Bioproc Engn, BR-13083852 Campinas - Brazil
[2] Fed Univ Rio Grande FURG, Sch Chem & Food Engn, BR-96203900 Rio Grande - Brazil
[3] Fed Univ Sao Paulo UNIFESP, Dept Biophys, Ctr Cell Therapy & Mol, BR-04044010 Sao Paulo - Brazil
Número total de Afiliações: 3
|
| Tipo de documento: | Artigo Científico |
| Fonte: | HARMACEUTIC; v. 14, n. 1 JAN 2022. |
| Citações Web of Science: | 0 |
| Resumo | |
Microfluidics is an emerging technology that can be employed as a powerful tool for designing lipid nano-microsized structures for biological applications. Those lipid structures can be used as carrying vehicles for a wide range of drugs and genetic materials. Microfluidic technology also allows the design of sustainable processes with less financial demand, while it can be scaled up using parallelization to increase production. From this perspective, this article reviews the recent advances in the synthesis of lipid-based nanostructures through microfluidics (liposomes, lipoplexes, lipid nanoparticles, core-shell nanoparticles, and biomimetic nanovesicles). Besides that, this review describes the recent microfluidic approaches to produce lipid micro-sized structures as giant unilamellar vesicles. New strategies are also described for the controlled release of the lipid payloads using microgels and droplet-based microfluidics. To address the importance of microfluidics for lipid-nanoparticle screening, an overview of how microfluidic systems can be used to mimic the cellular environment is also presented. Future trends and perspectives in designing novel nano and micro scales are also discussed herein. (AU) | |
| Processo FAPESP: | 15/20206-8 - Modulação de monócitos, macrófagos e pericitos pelos genes dos fatores estimuladores de colônia para tratamento de isquemia de membros em modelo murino |
| Beneficiário: | Sang Won Han |
| Modalidade de apoio: | Auxílio à Pesquisa - Temático |
| Processo FAPESP: | 18/18523-3 - Síntese de micropartículas poliméricas via processo microfluídico de gotas para a liberação sustentada de vetores não virais aplicados em terapia gênica |
| Beneficiário: | Bruna Gregatti de Carvalho |
| Modalidade de apoio: | Bolsas no Brasil - Doutorado Direto |
| Processo FAPESP: | 18/19537-8 - Microfluídica como plataforma tecnológica para nano & biotecnologia |
| Beneficiário: | Lucimara Gaziola de la Torre |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |