Beta tricalcium phosphate, either alone or in combination with antimicrobial photodynamic therapy or doxycycline, prevents medication-related osteonecrosis of the jaw

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Hadad, Henrique ; Kawamata de Jesus, Lais ; Piquera Santos, Ana Flavia ; Rinaldi Matheus, Henrique ; de Souza Rodrigues, Leticia Gabriella ; Paolo Poli, Pier ; Marcantonio Junior, Elcio ; Pozzi Semeghini Guastaldi, Fernando ; Maiorana, Carlo ; Milanezi de Almeida, Juliano ; Okamoto, Roberta ; Avila Souza, Francisley

• Tipo de documento: Artigo Científico
• Fonte: SCIENTIFIC REPORTS; v. 12, n. 1, p. 14-pg., 2022-10-03.

Resumo

Surgical trauma in those under a prolonged use of bisphosphonates, can lead to mediation-related osteonecrosis of the jaw (MRONJ). This study aimed to evaluate the preventive therapies for MRONJ. Following four cycles of zoledronic acid administration, Wistar rats had their molar extracted, and were organized into nine treatment groups: negative control group (NCG), treated with saline solution and blood-clot in the alveolus; positive control group (PCG), with blood-clot in the alveolus; BG, beta-tricalcium phosphate-based biomaterial; DG, 10% doxycycline gel; aG, antimicrobial photodynamic therapy; and DBG, aBG, aDG, and aDBG, using combination therapy. After 28 days, the lowest bone volume (BV/TV) was reported in PCG (42.17% +/- 2.65), and the highest in aDBG (69.85% +/- 6.25) (p < 0.05). The higher values of daily mineral apposition rate were recorded in aDBG (2.64 +/- 0.48) and DBG (2.30 +/- 0.37) (p < 0.001). Moreover, aDBG presented with the highest neoformed bone area (82.44% +/- 2.69) (p < 0.05). Non-vital bone was reported only in the PCG (37.94 +/- 18.70%). Owing to the key role of the biomaterial, the combination approach (aDBG) was the most effective in preventing MRONJ following tooth extraction. (AU)

• Processo FAPESP: 19/22657-8 - Prevenção da osteonecrose dos maxilares induzida por medicamentos com a utilização da terapia fotodinâmica. estudo experimental in vitro e in vivo
• Beneficiário: Henrique Hadad
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 19/27609-1 - Uso da terapia fotodinâmica, beta-tricalcio fosfato e doxiciclina no reparo alveolar de ratos induzidos a osteonecrose: análise por micro-tomografia e microscopia confocal a laser
• Beneficiário: Letícia Gabriella de Souza Rodrigues
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica