| Texto completo | |
| Autor(es): |
Katayama, Pedro L.
;
Leirao, Isabela P.
;
Kanashiro, Alexandre
;
Menani, Jose, V
;
Zoccal, Daniel B.
;
Colombari, Debora S. A.
;
Colombari, Eduardo
Número total de Autores: 7
|
| Tipo de documento: | Artigo Científico |
| Fonte: | FRONTIERS IN IMMUNOLOGY; v. 13, p. 10-pg., 2022-10-24. |
| Resumo | |
The idea that the nervous system communicates with the immune system to regulate physiological and pathological processes is not new. However, there is still much to learn about how these interactions occur under different conditions. The carotid body (CB) is a sensory organ located in the neck, classically known as the primary sensor of the oxygen (O-2) levels in the organism of mammals. When the partial pressure of O-2 in the arterial blood falls, the CB alerts the brain which coordinates cardiorespiratory responses to ensure adequate O(2 )supply to all tissues and organs in the body. A growing body of evidence, however, has demonstrated that the CB is much more than an O-2 sensor. Actually, the CB is a multimodal sensor with the extraordinary ability to detect a wide diversity of circulating molecules in the arterial blood, including inflammatory mediators. In this review, we introduce the literature supporting the role of the CB as a critical component of neuroimmune interactions. Based on ours and other studies, we propose a novel neuroimmune pathway in which the CB acts as a sensor of circulating inflammatory mediators and, in conditions of systemic inflammation, recruits a sympathetic-mediated counteracting mechanism that appears to be a protective response. (AU) | |
| Processo FAPESP: | 19/11196-0 - Mecanismos e circuitos neurais envolvidos na interação entre inflamação periférica e simpatoexcitação na Hipertensão Renovascular |
| Beneficiário: | Pedro Lourenço Katayama |
| Modalidade de apoio: | Bolsas no Brasil - Pós-Doutorado |
| Processo FAPESP: | 19/24154-3 - Desenvolvimento de novas ferramentas terapêuticas para o tratamento de doenças cardiovasculares |
| Beneficiário: | Eduardo Colombari |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |
| Processo FAPESP: | 15/23467-7 - Fisiopatologia experimental: mecanismos centrais de controle cardiovascular e respiratório envolvidos em modelos experimentais de hipertensão e obesidade |
| Beneficiário: | Eduardo Colombari |
| Modalidade de apoio: | Auxílio à Pesquisa - Temático |