| Texto completo | |
| Autor(es): |
Dias, Lucas D.
;
Bertolo, Mirella Romanelli, V
;
Alves, Fernanda
;
de Faria, Clara M. G.
;
Rodrigues, Murilo Alison, V
;
Lopes, Leticia Keller B. C.
;
de Guzzi Plepis, Ana Maria
;
Mattoso, Luiz Henrique C.
;
Bogusz Junior, Stanislau
;
Bagnato, Vanderlei S.
Número total de Autores: 10
|
| Tipo de documento: | Artigo Científico |
| Fonte: | MATERIALS TODAY COMMUNICATIONS; v. 31, p. 10-pg., 2022-06-01. |
| Resumo | |
The development of photoantimicrobial films for food and medical devices decontamination is a continuous challenge. In this work, chitosan/gelatin-based films containing curcumin and pomegranate peel extract in different concentrations (0.5-5.0 mg photosensitizer g(-1) solution) were prepared and characterized by ultraviolet-visible spectroscopy, fluorescence spectroscopy, infrared spectroscopy and scanning electron microscope; their structural morphology (thickness and moisture content, solubility and swelling degree, and opacity) was also analyzed. The photobleaching results (up to 90%) demonstrated a potential application of the films in antimicrobial photodynamic therapy (aPDT). In the antimicrobial tests, the films displayed a significant photoantimicrobial effect reducing Staphylococcus aureus up to 4 log units, using a light source at 450 and 525 nm (50 J cm(-2)) for curcumin and pomegranate peel extract films, respectively. The results of this work open way for future development of photoantimicrobial films based on natural polymers, containing photosensitizers, for medical devices (e.g.: endotracheal tubes and catheters) and food packaging. (AU) | |
| Processo FAPESP: | 19/18748-8 - Composição química de morangos recobertos com biofilmes a base de extratos de casca de romã, quitosana e gelatina |
| Beneficiário: | Mirella Romanelli Vicente Bertolo |
| Modalidade de apoio: | Bolsas no Brasil - Doutorado Direto |
| Processo FAPESP: | 14/50857-8 - INCT 2014 - de Óptica Básica e Aplicada às Ciências da Vida |
| Beneficiário: | Vanderlei Salvador Bagnato |
| Modalidade de apoio: | Auxílio à Pesquisa - Temático |
| Processo FAPESP: | 19/13569-8 - Estudo dos Mecanismos de Ação em Terapia Fotodinâmica: Do Fotossensibilizador à Aplicação Prática |
| Beneficiário: | Lucas Danilo Dias |
| Modalidade de apoio: | Bolsas no Brasil - Pós-Doutorado |