Bauhinia forficata link extract attenuates insulin resistance by preserving glucose uptake in gastrocnemius muscle

Autor(es)

Gasparini, Patricia ; Garofolo, Ingrid Candido ; Telles, Monica Marques ; Oyama, Lila Missae ; Veneza, Viviane de Mello ; Moura Veiga, Thiago Andre ; Flor Silveira, Vera Lucia ; Caperuto, Luciana Chagas

• Tipo de documento: Artigo Científico
• Fonte: NATURAL PRODUCT RESEARCH; v. N/A, p. 6-pg., 2022-08-16.

Resumo

Bioactive metabolites from Bauhinia forficata Link (Bf extract) hold therapeutic potential for type 2 diabetes mellitus (T2DM) but the mechanism remains poorly understood. This study aimed to test the extract from Bf leaves obtained by decoction on the prevention of T2DM in vivo. The Bf extract was tested on a streptozotocin-induced T2DM mouse model fed on a high-fat diet. The insulin resistance was attenuated in T2DM animals supplemented with Bf extract, which indicates glucose intolerance reduction and p-AKT/AKT ratio preservation in the gastrocnemius muscle. These observations suggested that Bf extract enhanced glucose uptake. Nevertheless, there was no preservation in beta-cell insulin secretion in Bf extract-treated T2DM mice. Interestingly, the Bf extract reduced body weight gain without affecting total energy intake. Hence, Bf extract has a hypoglycemic effect which could attenuate the development of insulin resistance. (AU)

• Processo FAPESP: 09/50041-0 - Regulação da expressão da BMP-9 em animais suplementados cronicamente com diferentes doses de L-arginina
• Beneficiário: Luciana Chagas Caperuto
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 17/02936-4 - Efeito de ácidos graxos poli-insaturados ômega 3 sobre a qualidade de oócitos e fertilidade em camundongos com Diabetes tipo 2
• Beneficiário: Vera Lucia Flor Silveira
• Modalidade de apoio: Auxílio à Pesquisa - Regular