Phase Singularities in a Cardiac Patch Model With a Non-conductive Fibrotic Area During Atrial Fibrillation

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Almeida, Tiago P. ; Nothstein, Mark ; Li, Xin ; Mase, Michela ; Ravelli, Flavia ; Soriano, Diogo C. ; Bezerra, Arthur S. ; Schlindwein, Fernando S. ; Yoneyama, Takashi ; Doessel, Olaf ; Ng, G. Andre ; Loewe, Axel ; IEEE

• Tipo de documento: Artigo Científico
• Fonte: 2020 COMPUTING IN CARDIOLOGY; v. N/A, p. 4-pg., 2020-01-01.

Resumo

In-silico cardiac patches with a non-conductive fibrotic areas were used to investigate the occurrence and characteristics of rotors described by phase singularities (PSs). A rotor was generated in a virtual tissue patch represented by a Courtemanche model adapted to mimic AF conditions. Non-conductive fibrotic elements were incorporated around the center of the patch (densities of 20%, 30%, and 40%). Electrograms (EGMs) were calculated and their phase was determined using Hilbert transform. PSs were detected and PS density maps (PSDMs) were generated. Six attributes were used to investigate bipolar EGMs obtained from the original signals: sample entropy (SampEn), determinism (DET), peak-to-peak (PP), wave similarity (WS), organization index (OI), and cycle length (CL). 77.1% of the PSs occurred inside the fibrotic region - with a higher density in the border zone - for 20% density; 99.8% for 30%; 99.7% for 40%. SampEn was significantly higher in regions with PSDM >= 5, while DET, PP, and WS were significantly lower (P<0.0001). PSs tended to meander outside the fibrotic area for lower fibrotic density. Bipolar EGM attributes offer a complementary way for rotor detection in the presence of non-conductive fibrosis. (AU)

• Processo FAPESP: 17/00319-8 - Identificação do substrato atrial em pacientes com fibrilação atrial crônica utilizando modelos estatísticos multivariados e múltiplos atributos de eletrogramas atriais
• Beneficiário: Tiago Paggi de Almeida
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 19/05192-1 - Classificação multivariável do substrato atrial durante fibrilação atrial crônica
• Beneficiário: Arthur Santos Bezerra
• Modalidade de apoio: Bolsas no Brasil - Mestrado
• Processo FAPESP: 18/02251-4 - Estudo da dinâmica da fibrilação atrial crônica utilizando modelos computacionais e análise de quantificação de recorrência
• Beneficiário: Tiago Paggi de Almeida
• Modalidade de apoio: Bolsas no Exterior - Estágio de Pesquisa - Pós-Doutorado
• Processo FAPESP: 19/09512-0 - Análise não linear da conectividade funcional dinâmica via quantificação de recorrência e sua aplicação em interfaces cérebro-computador
• Beneficiário: Diogo Coutinho Soriano
• Modalidade de apoio: Bolsas no Exterior - Pesquisa