Systemic conditions associated with increased risk to develop oral squamous cell carcinoma: Systematic review and meta-analysis

Autor(es)

Dos Santos, Erison Santana ; Perez-de-Oliveira, Maria Eduarda ; Costa Normando, Ana Gabriela ; Monteiro Gueiros, Luiz Alcino ; Rogatto, Silvia Regina ; Vargas, Pablo Agustin ; Lopes, Marcio Ajudarte ; da Silva Guerra, Eliete Neves ; Paes Leme, Adriana Franco ; Santos-Silva, Alan Roger

• Tipo de documento: Artigo Científico
• Fonte: HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK; v. 44, n. 12, p. 13-pg., 2022-09-16.

Resumo

This study aimed to map systemic alterations predisposing to oral squamous cell carcinoma (OSCC) onset. This review was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses. Five databases were used to access (1) reports of OSCC co-occurring in patients with systemic conditions, (2) prevalence of OSCC among these patients, and (3) clinicopathological profiles. Data from more than 1 million patients worldwide showed that Fanconi's anemia, xeroderma pigmentosum, dyskeratosis congenital, chronic fatigue syndrome, and patients post bone marrow transplantation (BMT) present increased risk for OSCC development. The overall prevalence of OSCC in syndromic patients and post-BMT were 0.65% (95% CI = 0.13-3.11, p < 0.01) and 5.83% (95% CI = 0.00-30.90, p < 0.01), respectively. The certainty of the evidence was moderate. This study demonstrated that some systemic conditions predispose to OSCC. These results present an impact on the screening of OSCC in systemically compromised patients. (AU)

• Processo FAPESP: 22/04490-1 - Validação de marcadores de transformação maligna para carcinoma de células escamosas oral por meio de imaging mass cytometry e proteômica baseada em alvos
• Beneficiário: Erison Santana dos Santos
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 19/09692-9 - Validação de proteínas-alvo associadas à progressão de lesões potencialmente malignas para Câncer Oral
• Beneficiário: Ana Gabriela Costa Normando
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 19/26676-7 - Desvendando o papel da translocação CRTC1-MAML2 no Carcinoma Mucoepidermoide de glândula salivar: um estudo clínico-patológico, molecular e proteômico
• Beneficiário: Maria Eduarda Pérez de Oliveira
• Modalidade de apoio: Bolsas no Brasil - Doutorado