Role of microRNAs in B-Cell Compartment: Development, Proliferation and Hematological Diseases

Autor(es)

Souza, Olivia Fonseca ; Popi, Ana Flavia

• Tipo de documento: Artigo Científico
• Fonte: BIOMEDICINES; v. 10, n. 8, p. 17-pg., 2022-08-01.

Resumo

B-cell development is a very orchestrated pathway that involves several molecules, such as transcription factors, cytokines, microRNAs, and also different cells. All these components maintain the ideal microenvironment and control B-cell differentiation. MicroRNAs are small non-coding RNAs that bind to target mRNA to control gene expression. These molecules could circulate in the body in a free form, protein-bounded, or encapsulated into extracellular vesicles, such as exosomes. The comprehension of the role of microRNAs in the B-cell development was possible based on microRNA profile of each B-cell stage and functional studies. Herein, we report the knowledge about microRNAs in the B-cell the differentiation, proliferation, and also in hematological malignancies. (AU)

• Processo FAPESP: 19/27009-4 - Avaliação de microRNAs e da via de apoptose em precursores de células B-1 ao longo do envelhecimento
• Beneficiário: Olívia Fonseca Souza
• Modalidade de apoio: Bolsas no Brasil - Doutorado Direto
• Processo FAPESP: 21/05377-1 - Alterações do perfil de miRNAs e impacto na sobrevivência de células B-1 e seus precursores durante o envelhecimento
• Beneficiário: Ana Flavia Popi
• Modalidade de apoio: Auxílio à Pesquisa - Regular