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Role of microRNAs in B-Cell Compartment: Development, Proliferation and Hematological Diseases

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Autor(es):
Souza, Olivia Fonseca ; Popi, Ana Flavia
Número total de Autores: 2
Tipo de documento: Artigo Científico
Fonte: BIOMEDICINES; v. 10, n. 8, p. 17-pg., 2022-08-01.
Resumo

B-cell development is a very orchestrated pathway that involves several molecules, such as transcription factors, cytokines, microRNAs, and also different cells. All these components maintain the ideal microenvironment and control B-cell differentiation. MicroRNAs are small non-coding RNAs that bind to target mRNA to control gene expression. These molecules could circulate in the body in a free form, protein-bounded, or encapsulated into extracellular vesicles, such as exosomes. The comprehension of the role of microRNAs in the B-cell development was possible based on microRNA profile of each B-cell stage and functional studies. Herein, we report the knowledge about microRNAs in the B-cell the differentiation, proliferation, and also in hematological malignancies. (AU)

Processo FAPESP: 19/27009-4 - Avaliação de microRNAs e da via de apoptose em precursores de células B-1 ao longo do envelhecimento
Beneficiário:Olívia Fonseca Souza
Modalidade de apoio: Bolsas no Brasil - Doutorado Direto
Processo FAPESP: 21/05377-1 - Alterações do perfil de miRNAs e impacto na sobrevivência de células B-1 e seus precursores durante o envelhecimento
Beneficiário:Ana Flavia Popi
Modalidade de apoio: Auxílio à Pesquisa - Regular